Trends in Simple and Complex Appendicitis in Children and the Potential Correlation to Common Viral Pathogens—A Retrospective Cohort Study between 2010 and 2019 in The Netherlands

The aim of this study was to evaluate the annual, seasonal and monthly trends in children with simple and complex appendicitis and their correlation to common viral pathogens in the Netherlands. A consecutive multicenter retrospective cohort study was performed between 2010 and 2019 including children ( p p = 0.011), but the variance was regarded as not relevant ( p = 0.026) and simple appendicitis with Adenovirus NON 40.41 (R = 0.332, 95%CI 0.019-0.586, p = 0.039), but these correlations did not remain significant after a Bonferroni correction ( p < 0.003). In conclusion, we found no relevant seasonal variation for simple or complex appendicitis, nor positive correlation with common viral pathogens

Appendicitis · Cohort · Cohort study · General surgery · Retrospective cohort study · Appendicitis Diagnosis and Management · Intestinal Malrotation and Obstruction Disorders · Intraperitoneal and Appendiceal Malignancies · Medicine · Epidemiology · Internal Medicine · Pediatrics