Pharmacoepidemiological Analysis of Oral Contraceptive Use in Adolescents in a German Longitudinal Cohort Study

Bibliographic Data

ID15714026
AuthorsMarkus Herzig (0000-0003-4435-7944, University Hospital Leipzig), Astrid Bertsche (0000-0003-2832-0156, Universitätsmedizin Greifswald), Cornelia Hilbert (University Hospital Leipzig), Wieland Kiess (0000-0003-4118-9455, University Hospital Leipzig), Thilo Bertsche (0000-0002-4930-6655, University Hospital Leipzig, corresponding author), Martina Patrizia Neininger (0000-0002-5208-0888, Leipzig University)
Year2023
Volume10
Issue2
Pages393-393
Publication date2023-02-16
Open AccessYes
TypeARTICLE
VenueChildren (JOURNAL)
Journal identifiersISSN: 2227-9067 • E-ISSN: 2227-9067
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/children10020393
PMID36832522
OpenAlexW4321230454
LanguageEN
References cited35

To assess the use of oral contraceptives (OC) in adolescents, using data from a longitudinal, population-based pediatric cohort study (LIFE Child). We also investigated associations between OC use and socioeconomic status (SES), and associations between OC use and potential adverse drug reactions such as effects on blood pressure. We included 609 female participants of the LIFE Child cohort, aged ≥13 to p = 0.013) and a decreased use of fourth-generation OC (2013: 71.8%, 2019: 45.5%; p = 0.027). We found a higher systolic (mean: 111.74 mmHg, p p = 0.004) blood pressure in OC users compared to non-users (systolic: 108.60 mmHg; diastolic: 67.24 mmHg). Every fourth adolescent took an OC. The share of second-generation OC increased during the study period. OC intake was associated with low SES. OC users had a slightly higher blood pressure than non-users

Anthropometry · Blood pressure · Cohort · Cohort study · Confidence interval · Environmental health · Odds ratio · Population · Demography · Global Maternal and Child Health · Maternal Mental Health During Pregnancy and Postpartum · Medicine · Reproductive Health and Contraception · Internal Medicine · Pediatrics

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