Novel Physique Index for the Screening of Skeletal Dysplasia at Birth
Bibliographic Data
| ID | 15714035 |
|---|---|
| Authors | Ryoji Aoki (0000-0002-9513-3863, Nihon University), Nobuhiko Nagano (0000-0002-0890-1626, Nihon University), Aya Okahashi (0009-0006-5750-7760, Nihon University), Shoko Ohashi (0000-0003-1212-8944, Tokyo Metropolitan Ohtsuka Hospital), Yoshinori Fujinaka (Tokyo Metropolitan Ohtsuka Hospital), Itsuro Takigawa (Tokyo Metropolitan Ohtsuka Hospital), Ken Masunaga (0000-0003-1235-2161, Tokyo Metropolitan Ohtsuka Hospital), Ichiro Morioka (0000-0002-5685-2670, Nihon University, corresponding author) |
| Year | 2021 |
| Volume | 8 |
| Issue | 5 |
| Pages | 331-331 |
| Publication date | 2021-04-25 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children8050331 |
| PMID | 33922881 |
| OpenAlex | W3157851895 |
| Language | EN |
| References cited | 20 |
This study aimed to devise a novel physique index and investigate its accuracy in identifying newborns with skeletal dysplasia in comparison with head circumference (HC)/height (HT) ratio. The birth weight (W), HT, and HC at birth of 1500 newborns were retrospectively collected. The linear regression equations and coefficients of determination (R 2 ) were determined. The formulated equation was corrected by the mean weight for gestational age at birth (Wcorr) as a novel physique index for screening skeletal dysplasia. The index accuracy was assessed using receiver operating characteristic (ROC) curves in 11 newborns by fetal ultrasound and compared with that of the HC/HT ratio. The R 2 values between W and HT, (HT) 2 , and (HT) 3 were 0.978, 0.990, and 0.993, respectively. Those between W and HC, (HC) 2 , and (HC) 3 were 0.974, 0.984, and 0.988, respectively. W/Wcorr × (HC/HT) 3 was used as a novel physique index. Seven newborns had skeletal dysplasia. Our novel physique index had a higher area under the curve (AUC), sensitivity, and specificity than the HC/HT ratio (AUC: 1.00 vs. 0.86, sensitivity: 1.00 vs. 0.86, and specificity: 1.00 vs. 0.75, respectively). Our novel physique index was more accurate than HC/HT ratio and has the potential to accurately identify newborns with skeletal dysplasia
Area under the curve · Biology · Birth weight · Dysplasia · Gestational age · Linear regression · Obstetrics · Pregnancy · Receiver operating characteristic · Statistics · Birth, Development, and Health · Connective tissue disorders research · Mathematics · Medicine · Neonatal Respiratory Health Research · Internal Medicine
| Highly cited | No |
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