Under-Vaccination in Pediatric Liver Transplant Candidates with Acute and Chronic Liver Disease—A Retrospective Observational Study of the European Reference Network TransplantChild
Bibliographic Data
| ID | 15714132 |
|---|---|
| Authors | Tobias Laue (0009-0003-3784-1444, Medizinische Hochschule Hannover, corresponding author), Zeynep Demir (0000-0002-2943-5767, Pediatric Hepatology Unit, Necker Enfants Malades Hospital, 75015 Paris, France), Dominique Debray (0000-0002-0345-963X, Pediatric Hepatology Unit, Necker Enfants Malades Hospital, 75015 Paris, France), Mara Cananzi (0000-0002-7177-2847, University of Padua), Paola Gaio (University of Padua), Valeria Casotti (Ospedale Papa Giovanni XXIII), Lorenzo D’Antiga (0000-0001-7150-3148, Ospedale Papa Giovanni XXIII), Vaidotas Urbonas (0000-0002-7779-5484, Vilnius University), Ulrich Baumann (0000-0002-0162-0266, Medizinische Hochschule Hannover) |
| Year | 2021 |
| Volume | 8 |
| Issue | 8 |
| Pages | 675-675 |
| Publication date | 2021-08-03 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children8080675 |
| PMID | 34438566 |
| OpenAlex | W3195221144 |
| Language | EN |
| Citations received | 2 |
| References cited | 19 |
Infection is a serious concern in the short and long term after pediatric liver transplantation. Vaccination represents an easy and cheap opportunity to reduce morbidity and mortality due to vaccine-preventable infection. This retrospective, observational, multi-center study examines the immunization status in pediatric liver transplant candidates at the time of transplantation and compares it to a control group of children with acute liver disease. Findings show only 80% were vaccinated age-appropriately, defined as having received the recommended number of vaccination doses for their age prior to transplantation; for DTP-PV-Hib, less than 75% for Hepatitis B and two-thirds for pneumococcal conjugate vaccine in children with chronic liver disease. Vaccination coverage for live vaccines is better compared to the acute control group with 81% versus 62% for measles, mumps and rubella ( p = 0.003) and 65% versus 55% for varicella ( p = 0.171). Nevertheless, a country-specific comparison with national reference data suggests a lower vaccination coverage in children with chronic liver disease. Our study reveals an under-vaccination in this high-risk group prior to transplantation and underlines the need to improve vaccination
Chronic liver disease · Cirrhosis · Disease · Immune system · Immunization · Liver transplantation · Measles · Measles-Mumps-Rubella Vaccine · Observational study · Retrospective cohort study · Rubella · Vaccination · Hepatitis B Virus Studies · Hepatitis Viruses Studies and Epidemiology · Medicine · Pediatric Hepatobiliary Diseases and Treatments · Immunology · Internal Medicine · Pediatrics · Transplantation
| Citations per year | 0.5 |
|---|---|
| Citation span | 2022 - 2022 (1) |
| Highly cited | No |