Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns
Bibliographic Data
| ID | 15714244 |
|---|---|
| Authors | Henrieta Hlisníková (0000-0003-0342-8830, Constantine the Philosopher University in Nitra, corresponding author), Branislav Kolena (0000-0003-1524-1512, Constantine the Philosopher University in Nitra), Miroslava Šidlovská (0000-0003-0641-7109, Constantine the Philosopher University in Nitra), M Mlynček (0000-0002-1292-4820, Constantine the Philosopher University in Nitra), Ida Petrovičová (0000-0003-0485-9392, Constantine the Philosopher University in Nitra) |
| Year | 2022 |
| Volume | 9 |
| Issue | 3 |
| Pages | 413-413 |
| Publication date | 2022-03-14 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children9030413 |
| PMID | 35327785 |
| OpenAlex | W4220689626 |
| Language | EN |
| Citations received | 1 |
| References cited | 4 |
Adverse birth outcomes present risk factors resulting in neonatal morbidity and mortality. Sufficient maternal hormonal concentrations are crucial for normal foetal development. Previous studies have shown a relationship between phthalate exposure and maternal hormonal levels during pregnancy. This study aims to investigate if neonatal anthropometric parameters are associated with maternal endocrine parameters during the ≤15th week of gestation and the third trimester of pregnancy concerning phthalate exposure in pregnant women from Nitra, Slovakia. We used high-performance liquid chromatography, tandem mass spectrometry (HPLC-MS/MS), and electro-chemiluminescence immunoassay to quantify urinary concentrations of phthalates and serum concentrations of hormones and sex hormone-binding globulin (SHBG), respectively. We observed a mostly positive correlation between neonatal anthropometric parameters (gestational age, birth length, birth weight, head circumference) and maternal concentration of phthalate metabolites ( p ≤ 0.05). The hierarchical multivariate regression results showed a statistically significant association between Apgar score at 5 min after delivery, gestational age, birth weight, head circumference, and maternal endocrine parameters during pregnancy ( p ≤ 0.05), adjusted to phthalate metabolites. To the best of our knowledge, our study is the first to indicate that prenatal exposure to phthalates may also affect birth outcomes through interaction with the maternal endocrine system
Biology · Birth weight · Gestation · Gestational age · Low birth weight · Obstetrics · Phthalate · Pregnancy · Birth, Development, and Health · Chemistry · Effects and risks of endocrine disrupting chemicals · Health, Environment, Cognitive Aging · Medicine · Endocrinology · Physiology
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| Citations per year | 0.25 |
|---|---|
| Citation span | 2022 - 2022 (1) |
| Highly cited | No |