Exploring the Association Between Attention-Deficit/Hyperactivity Disorder and Essential Hypertension in a Pediatric Population
Bibliographic Data
| ID | 15714323 |
|---|---|
| Authors | Eugene Merzon (0000-0001-5469-0236, Ariel University, corresponding author), May Poluksht (Ariel University), Shai Ashkenazi (0000-0001-7244-0679, Ariel University), Ehud Grossman (0000-0001-8353-0661, Ariel University), Eli Magen (0000-0002-7713-423X, Ben-Gurion University of the Negev), Akim Geishin (Clalit Health Services), Iris Manor (0000-0002-0642-0028, Tel Aviv University), Abraham Weizman (0000-0002-9765-8938, Tel Aviv University), Avivit Golan-Cohen (Tel Aviv University), Avivit Golan‐Cohen (0000-0003-2406-6402, Leumit Health Services, Tel Aviv-Yafo 6473817, Israel), Shlomo Vinker (0000-0001-9804-7103, Tel Aviv University), Ilan Green (0000-0002-9435-7152, Leumit Health Services, Tel Aviv-Yafo 6473817, Israel), Alexander Bershadsky (Clalit Health Services), Ariel Israel (0000-0003-4389-8896, Tel Aviv University) |
| Year | 2026 |
| Volume | 13 |
| Issue | 1 |
| Pages | 107-107 |
| Publication date | 2026-01-12 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children13010107 |
| PMID | 41597115 |
| OpenAlex | W7122743875 |
| Language | EN |
| References cited | 24 |
Objective : Current data on the association between attention-deficit/hyperactivity disorder (ADHD) and essential hypertension (EH) in pediatric populations are very limited, as most research has focused on adults. This study investigated the long-term prevalence of EH in Israeli youth aged 5-18 years with ADHD, examining also trends in antihypertensive medication use. Methods : A retrospective cohort study was conducted using data from Leumit Health Services. The ADHD cohort (N = 18,558) was compared in a 1:2 ratio to controls (N = 37,116), who were strictly matched for age, gender, birth year and quarter, socioeconomic status (SES), sectors, region, and cumulative years of LHS membership up to the index date. Diagnoses of ADHD and EH were identified using ICD-9/10 codes, depending on the year of diagnosis. Logistic regression analyses were used to assess the associations between ADHD, EH and the use of antihypertensive medications over a 20-year follow-up. Results : ADHD-diagnosed children had a higher prevalence of EH, with odds ratios (ORs) of 3.17 (95% CI: 1.46-7.16, p = 0.0017) at 5 years, 2.94 (95% CI: 1.45-6.09, p = 0.0013) at 10 years, and 1.92 (95% CI: 1.26-2.93, p = 0.0015) at 20 years. ADHD patients showed a greater use of antihypertensive medications, including calcium channel blockers (OR 1.85, 95% CI: 1.02-3.35, p = 0.035), renin angiotensin system blockers (OR 2.20, 95% CI: 1.15-4.25, p = 0.013), and diuretics (OR 1.77, 95% CI: 1.21-2.60, p = 0.0028). Conclusions : These findings highlight an association between ADHD diagnosis and EH, suggesting regular cardiovascular monitoring of children with ADHD. Further studies are needed to uncover the role of stimulant medications and shared biological and behavioral factors involved in the pathogenesis
Antihypertensive drug · Cohort · Cohort study · Essential hypertension · Logistic regression · Odds ratio · Socioeconomic status · Attention Deficit Hyperactivity Disorder · Functional Brain Connectivity Studies · Health, Environment, Cognitive Aging
| Citation velocity | historical |
|---|---|
| Highly cited | No |