Motor Learning Deficits in a Neonatal Mouse Model of Hypoxic-Ischemic Injury
Bibliographic Data
| ID | 15714380 |
|---|---|
| Authors | Maria Marlicz (0009-0004-4285-612X, University of Virginia), Weronika Matysik (0000-0002-1514-4969, University of Virginia), Emily Zucker (University of Virginia), Sarah Lee (0000-0001-9026-2802, University of Virginia), Hannah Mulhern (University of Virginia), Jennifer Burnsed (0000-0002-1902-1499, University of Virginia, corresponding author) |
| Year | 2024 |
| Volume | 12 |
| Issue | 1 |
| Pages | 27-27 |
| Publication date | 2024-12-27 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children12010027 |
| PMID | 39857858 |
| OpenAlex | W4405847829 |
| Language | EN |
| References cited | 21 |
Our findings demonstrate that young adult mice exposed to HI exhibit significant deficits and delayed learning in complex motor performance compared to sham mice. HI mice do not show deficits in gross motor performance; however, more subtle impairments are present in complex motor performance and learning. This HI model exhibits subtle motor deficits relevant to findings in humans and may be a useful tool in testing further neuroprotective strategies
Anesthesia · Cerebral palsy · Hippocampus · Hypoxia (environmental · Ischemia · Ligation · Motor activity · Motor coordination · Motor Learning · Motor skill · Neuroprotection · Oxygen · Pathology · Physical medicine and rehabilitation · Rotarod performance test · Sham surgery · Spatial learning · Chemistry · Medicine · Neonatal and fetal brain pathology · Neonatal Respiratory Health Research · Neuroscience · Neuroscience of respiration and sleep · Psychology · Internal Medicine
| Highly cited | No |
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