Multidisciplinary Approach for Hypothalamic Obesity in Children and Adolescents
A Preliminary Study
Bibliographic Data
| ID | 15714383 |
|---|---|
| Authors | Daniele Tessaris (0000-0002-6484-4371, Ospedale Regina Margherita, corresponding author), Patrizia Matarazzo (0000-0001-7601-786X, University of Turin), Gerdi Tuli (0000-0001-5862-8958, Ospedale Regina Margherita), Antonella Tuscano (University of Turin), Ivana Rabbone (0000-0003-4173-146X, Ospedale Regina Margherita), Alessandra Spinardi (University of Turin), Antonella Lezo (0000-0001-7603-1231, Ospedale Regina Margherita), Giorgia Fenocchio (Ospedale Regina Margherita), Raffaele Buganza (0000-0003-1850-2300, Ospedale Regina Margherita), Luisa De Sanctis (0000-0003-2113-6196, Ospedale Regina Margherita) |
| Year | 2021 |
| Volume | 8 |
| Issue | 7 |
| Pages | 531-531 |
| Publication date | 2021-06-22 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children8070531 |
| PMID | 34206290 |
| OpenAlex | W3177030786 |
| Language | EN |
| Citations received | 1 |
| References cited | 39 |
Hypothalamic obesity (HO) is delineated by an inexorable weight gain in subjects with hypothalamic disorder (congenital or acquired). The aim of the present study was to evaluate the effect of a multidisciplinary approach on weight trend and metabolic outcome in children and adolescents with hypothalamic disease who were overweight or obese. Thirteen patients (aged 8.1-16.1 years) received a personalized diet, accelerometer-based activity monitoring, and psychological assessment. Height, weight, body mass index (BMI), and serum metabolic parameters were assessed at baseline (T0) and after six months (T1). Metformin was introduced at T1 in four subjects who were then re-evaluated after six months (T2). At T1, weight gain was significantly reduced compared with T0 (0.29 ± 0.79 kg/month vs. 0.84 ± 0.55 kg/month, p = 0.03), and weight standard deviation score (SDS) and BMI SDS did not change significantly, as serum metabolic parameters. The four subjects treated with metformin showed a reduction of weight SDS and BMI SDS at T2. In conclusion, patients treated with our multidisciplinary approach showed, after 6 months, favorable results characterized by decreased weight gain and stabilization of weight SDS and BMI SDS in a condition usually characterized by inexorable weight gain. However, further analysis, larger cohorts, and longer follow-up are needed to confirm these preliminary data
Body mass index · Body weight · Insulin · Metformin · Obesity · Overweight · Weight gain · Weight loss · Child Nutrition and Feeding Issues · Childhood Cancer Survivors' Quality of Life · Genetics and Neurodevelopmental Disorders · Medicine · Endocrinology · Internal Medicine · Pediatrics
| Citations per year | 0.25 |
|---|---|
| Citation span | 2022 - 2022 (1) |
| Highly cited | No |