Association Between Serum Caffeine Concentrations, Intermittent Hypoxia and Apnea in Preterm Infants
A Prospective Observational Study
Bibliographic Data
| ID | 15714899 |
|---|---|
| Authors | Gonca Vardar (0000-0002-6221-005X, Marmara University, corresponding author), Demet Oğuz (0000-0003-0727-4875, Sağlık Bilimleri Üniversitesi), İlker Uslu (Sağlık Bilimleri Üniversitesi), Sinem Gülcan Kersin (0000-0003-3634-3243, Marmara University), Merih Cetinkaya (Sağlık Bilimleri Üniversitesi), Eren Özek (0000-0002-6419-5068, Marmara University) |
| Year | 2026 |
| Volume | 13 |
| Issue | 1 |
| Pages | 85-85 |
| Publication date | 2026-01-06 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children13010085 |
| PMID | 41597093 |
| OpenAlex | W7119107796 |
| Language | EN |
| References cited | 27 |
While serum caffeine concentrations in preterm infants did not vary significantly with gestational age, lower levels were associated with a higher incidence of AOP and IH episodes. These results suggest that while routine monitoring or dose adjustment based solely on gestational age may not be warranted, maintaining adequate serum levels is critical for symptom management. Future research should prioritize randomized controlled trials with expanded sample sizes, extended follow-up periods, and a rigorous analysis of adverse effects
Apnea · Apnea of prematurity · Caffeine · Gestation · Gestational age · Incidence (geometry · Intermittent hypoxia · Observational study · Randomized controlled trial · Cardiovascular Conditions and Treatments · Neonatal Respiratory Health Research · Neuroscience of respiration and sleep
| Highly cited | No |
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