Antibiotic Resistance Patterns of Uropathogens Causing Urinary Tract Infections in Children with Congenital Anomalies of Kidney and Urinary Tract

Bibliographic Data

ID15715001
AuthorsRaluca Isac (0000-0003-1478-9797, Victor Babeș University of Medicine and Pharmacy Timișoara), Diana-Georgiana Basaca (0000-0002-4599-0912, Emergency Hospital for Children “Louis Turcanu”, 300011 Timișoara, Romania), Ioana-Cristina Olariu (Victor Babeș University of Medicine and Pharmacy Timișoara), Ramona Stroescu (0000-0002-4403-0581, Victor Babeș University of Medicine and Pharmacy Timișoara), Ramona F Stroescu (Emergency Hospital for Children “Louis Turcanu”, 300011 Timișoara, Romania), Andrada-Mara Ardelean (0000-0001-6831-4776, Victor Babeș University of Medicine and Pharmacy Timișoara), Ruxandra Maria Steflea (0000-0002-8033-4785, Victor Babeș University of Medicine and Pharmacy Timișoara), Mihai Gafencu (0000-0002-9029-5919, Victor Babeș University of Medicine and Pharmacy Timișoara), Adela Chiriţă-Emandi (0000-0001-7554-4625, Victor Babeș University of Medicine and Pharmacy Timișoara), Iulia Cristina Bagiu (0000-0003-3099-8249, Victor Babeș University of Medicine and Pharmacy Timișoara, corresponding author), Florin George Horhat (0000-0001-6133-0204, Victor Babeș University of Medicine and Pharmacy Timișoara, corresponding author), Dan Dumitru Vulcănescu (0000-0003-1046-7272), Dan-Dumitru Vulcanescu (Emergency Hospital for Children “Louis Turcanu”, 300011 Timișoara, Romania), Dan Ionescu (0000-0001-7171-2409, Polytechnic University of Timişoara), Gabriela Doroș (0000-0003-2277-4034, Victor Babeș University of Medicine and Pharmacy Timișoara)
Year2021
Volume8
Issue7
Pages585-585
Publication date2021-07-08
Open AccessYes
TypeARTICLE
VenueChildren (JOURNAL)
Journal identifiersISSN: 2227-9067 • E-ISSN: 2227-9067
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/children8070585
PMID34356564
OpenAlexW3178632954
LanguageEN
Citations received2
References cited36

Background: Urinary tract infections (UTI) are common in children worldwide. Congenital anomalies of kidney and urinary tract (CAKUT) increase the risk of UTI and consequently antibiotic resistance. Antibiotic resistance represents an important public health issue worldwide. We aimed to evaluate the local trend in terms of bacterial uropathogen resistance in the western part of Romania in children with CAKUT and UTI. Methods: 252 children with CAKUT were admitted to our hospital over a five-year period. Of them, 91 developed at least one UTI episode, with a total number of 260 positive urine cultures. We collected data about age at diagnosis of CAKUT, sex, origin environment, type and side of CAKUT, number of UTIs, type of uropathogen, and uropathogens antibiotic resistance. Results: Distribution of uropathogens was Escherichia coli (38.84%), Klebsiella spp. (21.15%), Enterococcus spp. (15.76%), Proteus spp. (8.07%), Pseudomonas spp. (8.07%), Enterobacter spp. (2.3%), other Gram-negative bacteria (2.3%), and other Gram-positive bacteria (3.45%). High antibiotic resistance was detected for ampicillin, amoxicillin, and second-generation cephalosporins. Escherichia coli presented high resistance for cefepime and ceftriaxone. Pseudomonas spp. remained susceptible to amikacin, quinolones, and colistin. Vancomycin, teicoplanin, linezolid, and piperacillin/tazobactam remained effective in treating Gram-positive UTI. Conclusions: High antibiotic resistance was identified for frequently used antibiotics. Lower antibiotic resistance was observed for some broad-spectrum antibiotics. Understanding uropathogens' antibiotic resistance is important in creating treatment recommendations, based on international guidelines, local resistance patterns, and patient particularities

Amikacin · Amoxicillin · Ampicillin · Antibiotic resistance · Antibiotics · Aztreonam · Bacteria · Biology · Ceftriaxone · Enterobacter · Escherichia coli · Imipenem · Nitrofurantoin · Piperacillin · Pseudomonas aeruginosa · Tazobactam · Medicine · Pediatric Urology and Nephrology Studies · Urinary Tract Infections Management · Urological Disorders and Treatments · Microbiology

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