Maternal Risk Factors Associated with Limb Reduction Defects

Data from the Polish Registry of Congenital Malformations (PRCM)

Bibliographic Data

ID15715369
AuthorsAnna Materna‐Kiryluk (0000-0002-2889-5892, Poznan University of Medical Sciences, corresponding author), Katarzyna Wiśniewska (0000-0003-0025-1398, Poznan University of Medical Sciences), Barbara Więckowska (0000-0002-1811-2583, Poznan University of Medical Sciences), Jolanta Wierzba (0000-0003-0290-1243, Gdańsk Medical University), Anna М Jażdżewska (0000-0003-2529-0641), Anna Jazdzewska (Surgery and Burn Treatment Unit, Specialist Mother and Child Healthcare Centre in Poznan, 61-825 Poznan, Poland), Beata Jaroszewska-Świątek (0000-0001-6685-3346, University of Warmia and Mazury in Olsztyn), Kinga Skotnicka (Poznan University of Medical Sciences), Anna Latos‐Bieleńska (0000-0002-9152-1674, Poznan University of Medical Sciences), Anna Latos-Bielenska (Polish Registry of Congenital Malformations, Chair and Department of Medical Genetics, University of Medical Sciences, 61-701 Poznan, Poland)
Year2021
Volume8
Issue2
Pages138-138
Publication date2021-02-12
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueChildren (JOURNAL)
Journal identifiersISSN: 2227-9067 • E-ISSN: 2227-9067
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/children8020138
PMID33673226
OpenAlexW3131406157
LanguageEN
References cited48

Data from the Polish Registry of Congenital Malformations (PRCM) suggest that the prevalence of limb reduction defects (LRDs) in some Polish regions is significantly higher in comparison to that reported in the European Surveillance of Congenital Anomalies (EUROCAT) registry, but specific risk factors are still unknown. The objectives of this study were two-fold: to detect risk factors linked to isolated LRDs among Polish natives and to search for geospatial clusters of isolated LRDs to identify high-risk areas across the country. Among the 2,939,001 births accounted for in the PRCM, we determined that there were 852 children with distinct LRDs. Our data demonstrate that lower birth weight, prematurity, and maternal smoking history are strongly associated with isolated LRDs. Furthermore, our investigation pointed to various additional risk factors for isolated LRDs, including paternal education, gestational hypertension, upper respiratory tract infections, and exposure to anti-inflammatory drugs in the first trimester of pregnancy. We did not recognize statistically significant spatial or spatiotemporal clusters over the area of Poland using Kulldorff's scan. Our study strengthens the hypothesis that maternal factors have an integral role in the etiology of isolated LRDs

Biology · Congenital malformations · Etiology · Pathology · Pregnancy · Risk factor · Congenital Anomalies and Fetal Surgery · Congenital limb and hand anomalies · Medicine · Prenatal Screening and Diagnostics · Pediatrics

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