The Neutrophil-to-Lymphocyte Ratio (NLR) Can Predict Sepsis’s Presence and Severity in Malnourished Infants—A Single Center Experience
Bibliographic Data
| ID | 15715468 |
|---|---|
| Authors | Alina Emilia Domnicu (Victor Babeș University of Medicine and Pharmacy Timișoara), Eugen Radu Boia (Victor Babeș University of Medicine and Pharmacy Timișoara, corresponding author), Mirela Mogoi (0000-0002-3923-3501, Victor Babeș University of Medicine and Pharmacy Timișoara), Aniko-Maria Manea (Victor Babeș University of Medicine and Pharmacy Timișoara), Tamara Marcela Marcovici (Victor Babeș University of Medicine and Pharmacy Timișoara), Otilia Mărginean (0000-0003-2313-7643, Victor Babeș University of Medicine and Pharmacy Timișoara), Marioara Boia (Victor Babeș University of Medicine and Pharmacy Timișoara) |
| Year | 2023 |
| Volume | 10 |
| Issue | 10 |
| Pages | 1616-1616 |
| Publication date | 2023-09-28 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children10101616 |
| PMID | 37892278 |
| OpenAlex | W4387119071 |
| Language | EN |
| Citations received | 1 |
| References cited | 65 |
Sepsis represents one of the leading causes of death in newborns and infants, and prompt diagnosis is essential for achieving favorable outcomes. Regarding malnourished children with concurrent infection, most studies have focused, besides blood culture, on C-reactive protein and procalcitonin. Because malnutrition has a deleterious effect on cellular immune competence, the present study characterized the acute-phase response, including hematological indices, in response to sepsis. Among the examined laboratory biomarkers, procalcitonin and neutrophil-to-lymphocyte ratio were the most accurate discriminators between sepsis patients and those with bacterial infection. Moreover, these two parameters showed a gradual increase between sepsis, severe sepsis, and septic shock patients ( p < 0.001). Subgroup analysis of the sepsis group revealed positive correlations of NLR with prolonged ICU stay (<0.001), acute organ dysfunction (0.038), mechanical ventilation (<0.001), and fatality (<0.001). In summary, our results suggest that the neutrophil-to-lymphocyte ratio can be used as an auxiliary diagnostic index in discriminating the presence and severity of bacterial sepsis in malnourished infants
Lymphocyte · Procalcitonin · Sepsis · Septic shock · Single Center · Medicine · Neonatal and fetal brain pathology · Neonatal and Maternal Infections · Sepsis Diagnosis and Treatment · Gastroenterology · Immunology · Internal Medicine
| Citations per year | 0.5 |
|---|---|
| Citation span | 2024 - 2024 (1) |
| Highly cited | No |