Sleep and Inflammation during Covid-19 Virtual Learning in Adolescents with Overweight or Obesity

Bibliographic Data

ID15716451
AuthorsLindsay M Stager (0000-0002-0794-4990, University of Alabama at Birmingham), Casie H Morgan (0000-0002-1515-6548, University of Alabama at Birmingham), Caroline Watson (University of Alabama at Birmingham), Caroline S Watson (Department of Psychology, University of Alabama at Birmingham, 1300 University Blvd, Birmingham, AL 35233, USA), Aaron D Fobian (0000-0001-9974-8534, University of Alabama at Birmingham, corresponding author)
Year2023
Volume10
Issue12
Pages1833-1833
Publication date2023-11-21
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueChildren (JOURNAL)
Journal identifiersISSN: 2227-9067 • E-ISSN: 2227-9067
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/children10121833
PMID38136035
OpenAlexW4388858863
LanguageEN
References cited37

(1) Background: Adolescents present as a high-risk group for a range of adverse physical health outcomes during the pandemic, including sleep and C-reactive protein (CRP) levels. As adolescents with overweight or obesity (OWOB) present as an even higher risk group, the present study assessed relationships between sleep and CRP levels before and during COVID-19 in adolescents with OWOB. (2) Methods: Fourteen adolescents with OWOB participated in a pre-COVID1, pre-COVID2, and during-COVID-19 lab visit, measuring sleep and CRP levels. The sample size was limited by the number of participants who provided data before COVID-19 and who were enrolled in virtual school during the recruitment phase. However, our power analyses indicated needing a minimum of 10 participants to achieve adequate power. Pre-COVID1, pre-COVID2, and during-COVID-19 normative expected CRP levels were calculated based on age, sex, race, and body mass index percentile-matched data. Analyses compared pre-COVID1 and pre-COVID2 sleep with during-COVID-19 sleep, during-COVID-19 sleep and during-COVID-19 CRP levels, during-COVID-19 CRP levels with normative expected during-COVID-19 CRP levels, change in CRP levels from pre-COVID1 and pre-COVID2 to during-COVID-19 with normative expected CRP levels during those time periods, and change in CRP levels before COVID-19 with change in CRP levels during COVID-19. (3) Results. During COVID-19, participants experienced decreased sleep efficiency ( p = 0.001), later wake time ( p p = 0.021), and onset latency ( p = 0.004), compared to pre-COVID1, and decreased sleep efficiency ( p = 0.002), longer onset latency ( p = 0.006), and later wake time ( p p = 0.016) compared with pre-COVID2. During-COVID-19 CRP levels were positively correlated with during-COVID-19 wake times ( p = 0.01) and times in bed ( p = 0.008). During-COVID-19 CRP levels were greater than normative expected CRP levels ( p p < 0.003). Changes in CRP levels before and during COVID-19 were not significantly different. (4) Conclusions. These findings highlight the consequential effects of COVID-19, including impairments in sleep, on adolescents with OWOB. CRP levels increased more (~5 mg/L) during COVID-19 than normative expected change

2019-20 coronavirus outbreak · Coronavirus disease 2019 (COVID-19 · Disease · Inflammation · Obesity · Outbreak · Overweight · Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 · Sleep (system call · Computer Science · COVID-19 and Mental Health · Eating Disorders and Behaviors · Medicine · Psychology · Sleep and related disorders · Internal Medicine · Virology

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