Grading of Intraventricular Hemorrhage and Neurodevelopment in Preterm <29 Weeks’ GA in Canada
Bibliographic Data
| ID | 15716459 |
|---|---|
| Authors | Vibhuti Shah (0000-0001-8685-2447, Mount Sinai Hospital, corresponding author), Natasha Musrap (Mount Sinai Hospital), Krishanta Maharaj (Mount Sinai Hospital), Jehier Afifi (0000-0001-7651-3054, Dalhousie University), Walid El‐Naggar (0000-0001-6657-4507, Dalhousie University), Walid El-Naggar (Dalhousie University), Edmond Kelly (Mount Sinai Hospital), Edmond N Kelly (0000-0003-0271-4720, Mount Sinai Hospital), Amit Mukerji (0000-0003-2609-9240, McMaster University), Prakesh S Shah (0000-0002-9920-0488, Mount Sinai Hospital), Prakesh Shah (Mount Sinai Hospital), Michael Vincer (Dalhousie University) |
| Year | 2022 |
| Volume | 9 |
| Issue | 12 |
| Pages | 1948-1948 |
| Publication date | 2022-12-12 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children9121948 |
| PMID | 36553391 |
| OpenAlex | W4312133575 |
| Language | EN |
| References cited | 27 |
Objective: The aim of this study was to evaluate the neurodevelopmental outcome at 18−24 months in surviving preterm infants with grades I−IV intraventricular hemorrhages (IVHs) compared to those with no IVH. Study Design: We included preterm survivors <29 weeks’ GA admitted to the Canadian Neonatal Network’s NICUs from April 2009 to September 2011 with follow-up data at 18−24 months in a retrospective cohort study. The neonates were grouped based on the severity of the IVH detected on a cranial ultrasound scan and recorded in the database: no IVH; subependymal hemorrhage or IVH without ventricular dilation (grades I−II); IVH with ventricular dilation (grade III); and persistent parenchymal echogenicity/lucency (grade IV). The primary outcomes of neurodevelopmental impairment (NDI), significant neurodevelopmental impairment (sNDI), and the effect modification by other short-term neonatal morbidities were assessed. Using multivariable regression analysis, the adjusted ORs (AOR) and 95% of the CIs were calculated. Results: 2327 infants were included. The odds of NDI were higher in infants with grades III and IV IVHs (AOR 2.58, 95% CI 1.56, 4.28 and AOR 2.61, 95% CI 1.80, 3.80, respectively) compared to those without IVH. Infants with an IVH grade ≤II had similar outcomes for NDI (AOR 1.08, 95% CI 0.86, 1.35) compared to those without an IVH, but the odds of sNDI were higher (AOR 1.58, 95% CI 1.16, 2.17). Conclusions: There were increased odds of sNDI in infants with grades I−II IVHs, and an increased risk of adverse NDI in infants with grades ≥III IVHs is corroborated with the current literature
Bronchopulmonary dysplasia · Gestational age · Intraventricular hemorrhage · Odds ratio · Pregnancy · Retrospective cohort study · Medicine · Neonatal and fetal brain pathology · Neonatal Respiratory Health Research · Neuroscience of respiration and sleep · Internal Medicine · Pediatrics
| Highly cited | No |
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