Renal Involvement in Multisystem Inflammatory Syndrome in Children

Kidney involvement has been poorly investigated in SARS-CoV-2 Multisystem Inflammatory Syndrome in Children (MIS-C). To analyze the spectrum of renal involvement in MIS-C, we performed a single-center retrospective observational study including all MIS-C patients diagnosed at our Pediatric Department between April 2020 and May 2022. Demographic, clinical, pediatric intensive care unit (PICU) admission's need and laboratory data were collected at onset and after 6 months. Among 55 MIS-C patients enrolled in the study, kidney involvement was present in 20 (36.4%): 13 with acute kidney injury (AKI) and 7 with isolated tubular dysfunction (TD). In eight patients, concomitant AKI and TD was present (AKI-TD). AKI patients needed higher levels of intensive care (PICU: 61.5%, p p = 0.002; second-line immuno-therapy: 53.8%, p p = 0.012), higher inflammatory markers [neutrophils ( p = 0.092), PCT ( p = 0.04), IL-6 ( p = 0.007)] as compared to no-AKI. TD markers showed that isolated TD presented higher levels of HCO3- and lower inflammatory markers than AKI-TD. Our results indicate a combination of both pre-renal and inflammatory damage in the pathogenesis of kidney injury in MIS-C syndrome. We highlight, for the first time, the presence of tubular involvement in MIS-C, providing new insights in the evaluation of kidney involvement and its management in this condition

Acute kidney injury · Concomitant · Intensive care medicine · Intensive care unit · Kidney · Kidney disease · Multiple organ dysfunction syndrome · Pathogenesis · Pediatric intensive care unit · Sepsis · Systemic inflammatory response syndrome · COVID-19 Clinical Research Studies · COVID-19 Impact on Reproduction · Kawasaki Disease and Coronary Complications · Medicine · Gastroenterology · Internal Medicine

• Long-Term Kidney Outcomes After Sars-CoV-2 Infection in Children Aged 0–12 Years

  Open Access•Saad Alhumaid, Abdullah Abdulrahman Alkhamees et al.•Children•2026

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