Efficacy of Sildenafil in Infants with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension
Bibliographic Data
| ID | 15717179 |
|---|---|
| Authors | Kacie Dillon (University of Tennessee Health Science Center), Vineet Lamba (University of Tennessee Health Science Center), Ranjit Philip (0000-0003-3748-0215, University of Tennessee Health Science Center), Mark Weems (0000-0003-3518-8376, University of Tennessee Health Science Center), Ajay J Talati (0000-0002-7980-3679, corresponding author), Ajay Talati (0000-0003-1798-9970, University of Tennessee Health Science Center, corresponding author) |
| Year | 2023 |
| Volume | 10 |
| Issue | 8 |
| Pages | 1397-1397 |
| Publication date | 2023-08-16 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children10081397 |
| PMID | 37628395 |
| OpenAlex | W4385879143 |
| Language | EN |
| References cited | 16 |
Background: Pulmonary hypertension (PH) is a common comorbidity in infants with bronchopulmonary dysplasia (BPD). Sildenafil is a widely recognized therapy for PH, but its efficacy in infants with BPD is questionable. We propose to assess the efficacy of sildenafil in BPD-associated PH as evaluated based on transthoracic echocardiography (TTE) changes and clinical measures. Methods: Data were retrospectively and prospectively collected. Inclusion criteria were gestational age (GA) Results: In total, 19 patients were enrolled in the study, having a median GA of 24 3/7 weeks (IQR 23 5/7-25 5/7) and a median BW of 598 g (IQR 572-735). Sildenafil treatment was started at a median PMA of 40.4 weeks. The median respiratory severity score (RSS) at 28 d was 6.5, RSS and FiO2 showed improvement about 12 weeks after starting sildenafil treatment. Conclusions: Improvement in PH was noted via TTE, and patients had improvement in their RSS and FiO2 after prolonged therapy. However, TTE improvements did not correlate with clinical improvements
Bronchopulmonary dysplasia · Cardiology · Gestational age · Pregnancy · Pulmonary hypertension · Sildenafil · Congenital Diaphragmatic Hernia Studies · Congenital Heart Disease Studies · Medicine · Neonatal Respiratory Health Research · Internal Medicine · Pediatrics
| Highly cited | No |
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