Pragmatic Markers in the Management of Asthma
A Real-World-Based Approach
Bibliographic Data
| ID | 15717540 |
|---|---|
| Authors | Giorgio Ciprandi (0000-0001-7016-8421, Casa di Cura Columbus, corresponding author), Gian Luigi Marseglia (0000-0003-3662-0159, University of Pavia), Fabio Luigi Massimo Ricciardolo (0000-0003-1826-5018, University of Turin), Maria Angela Tosca (0000-0002-0866-8940, Istituto Giannina Gaslini) |
| Year | 2020 |
| Volume | 7 |
| Issue | 5 |
| Pages | 48-48 |
| Publication date | 2020-05-18 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children7050048 |
| PMID | 32443418 |
| OpenAlex | W3027525255 |
| Language | EN |
| References cited | 66 |
Bronchial hyperreactivity, reversible airflow limitation and chronic airway inflammation characterize asthma pathophysiology. Personalized medicine, i.e., a tailored management approach, is appropriate for asthma management and is based on the identification of peculiar phenotypes and endotypes. Biomarkers are necessary for defining phenotypes and endotypes. Several biomarkers have been described in asthma, but most of them are experimental and/or not commonly available. The current paper will, therefore, present pragmatic biomarkers useful for asthma management that are available in daily clinical practice. In this regard, eosinophil assessment and serum allergen-specific IgE assay are the most reliable biomarkers. Lung function, mainly concerning forced expiratory flow at 25-755 of vital capacity (FEF 25-75 ), and nasal cytology may be envisaged as ancillary biomarkers in asthma management. In conclusion, biomarkers have clinical relevance in asthma concerning both the endotype definition and the personalization of the therapy
Asthma · Asthma management · Bioinformatics · Biomarker · Endotype · Eosinophil · Immunoglobulin E · Intensive care medicine · Lung · Lung function · Pathology · Personalized medicine · Precision medicine · Asthma and respiratory diseases · IL-33, ST2, and ILC Pathways · Medicine · Respiratory and Cough-Related Research · Immunology · Internal Medicine
| Citation velocity | historical |
|---|---|
| Highly cited | No |