Comparison between Short Therapy and Standard Therapy in Pediatric Patients Hospitalized with Urinary Tract Infection
A Single Center Retrospective Analysis
Bibliographic Data
| ID | 15717629 |
|---|---|
| Authors | Danilo Buonsenso (0000-0001-8567-2639, Università Cattolica del Sacro Cuore, corresponding author), Giorgio Sodero (0000-0003-3711-4928, Agostino Gemelli University Polyclinic), Francesco Mariani (0000-0002-1142-6678, Agostino Gemelli University Polyclinic), Ilaria Lazzareschi (Agostino Gemelli University Polyclinic), Francesco Proli (0000-0003-2426-3342, Agostino Gemelli University Polyclinic), Giuseppe Zampino (0000-0002-2661-4831, Agostino Gemelli University Polyclinic), Luca Pierantoni (0000-0001-8175-5488, Azienda USL di Bologna), Piero Valentini (0000-0001-6095-9510, Agostino Gemelli University Polyclinic), Claudia Rendeli (0000-0002-5948-1617, Agostino Gemelli University Polyclinic) |
| Year | 2022 |
| Volume | 9 |
| Issue | 11 |
| Pages | 1647-1647 |
| Publication date | 2022-10-28 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children9111647 |
| PMID | 36360375 |
| OpenAlex | W4307946123 |
| Language | EN |
| Citations received | 1 |
| References cited | 27 |
Introduction: There is marked heterogeneity in clinicians’ choice of antibiotic duration for pediatric urinary tract infections (UTIs). Most patients with bacterial UTIs still receive between 7 and 10 days of antibiotics. Prolonged antibiotic exposure drives the emergence of resistance and increases the occurrence of adverse effects. There is increasing evidence that shorter antibiotic regimens may be equally effective compared with longer ones. However, studies evaluating shorter therapies in children hospitalized with urinary tract infections have not yet been performed. Methods: We performed a retrospective study comparing children hospitalized with UTIs treated with a short antibiotic (<7 days) or standard antibiotic treatment. The primary aim of our study was to assess the efficacy of a shorter antibiotic therapy for children with UTIs, compared with an historical group of children treated with a standard 7−14 days course. Results: 112 patients, 46 of which were females (41.1%) with a median age 6 months were enrolled. A total of 33 patients (29.5%) underwent a short therapy. All patients were successfully discharged from the acute episode, independently from antibiotic duration. Short therapy was associated with a lower risk of urinary tract relapse (22 relapses (95.6%) in the standard group, 1 (4.4%) in the short group; OR 0.081; 95%CI 0.01−0.63). Conclusions: Short antibiotic therapy was equivalent to standard duration therapy for the cure of UTIs in hospitalized children and was also associated with a lower rate of recurrences. This study provides the basis for a larger prospective randomized study to address the role of short antibiotic therapies in children with UTIs requiring hospitalization
Adverse effect · Antibiotic therapy · Antibiotics · Retrospective cohort study · Single Center · Urinary system · Medicine · Pediatric Urology and Nephrology Studies · Urinary Bladder and Prostate Research · Urinary Tract Infections Management · Internal Medicine · Pediatrics · Surgery
| Unique citing works | 1 |
|---|---|
| Citations per year | 0.33 |
| Citation span | 2023 - 2023 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |