Severe Covid-19 Pneumonia in a Three-Year-Old with Congenital Iron and B12 Deficiency Anemia of Unknown Etiology
A Case Report
Bibliographic Data
| ID | 15717697 |
|---|---|
| Authors | Theodore Daniel Liapman (0000-0001-7176-3935, University of Ulster, corresponding author), Jurijs Bormotovs (Children's Clinical University Hospital), Dace Reihmane (0000-0003-4929-4436, Riga Stradiņš University) |
| Year | 2023 |
| Volume | 10 |
| Issue | 4 |
| Pages | 616-616 |
| Publication date | 2023-03-24 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children10040616 |
| PMID | 37189864 |
| OpenAlex | W4360845896 |
| Language | EN |
| References cited | 27 |
Since COVID-19 first emerged in Wuhan, China, and was declared a global pandemic by the WHO, researchers have been meticulously studying the disease and its complications. Studies of severe COVID-19 disease among pediatric populations are scarce, leading to difficulty in establishing a comprehensive management approach. Case presentation: This report outlines a case of a long-standing combined iron and vitamin B12 deficiency anemia in a three-year-old treated at the Children's Clinical University Hospital due to severe COVID-19 disease. The patient's clinical condition coincided with the derangement of biomarkers described in the literature, including lymphopenia, increased neutrophil/lymphocyte ratio (NLR), decreased lymphocyte/C-reactive protein ratio (LCR), as well as elevated inflammatory markers such as CRP and D-dimers. The patient developed severe bilateral pneumonia requiring invasive ventilation, high-flow oxygen, immunosuppressive therapy with dexamethasone and tocilizumab, and supplementation of anemia deficits with blood transfusion and vitamin B12 administration. Conclusions: Our findings are consistent with the most important biomarkers reported in the literature indicative of severe disease progression. Additionally, poorly controlled anemia may be suggested as a potentially important risk factor for severe COVID-19 disease among children. However, additional quantitative research is required to establish the nature and severity of the risk
Anemia · Coronavirus disease 2019 (COVID-19 · Disease · Etiology · Infectious disease (medical specialty · Iron deficiency · Iron-deficiency anemia · Pneumonia · COVID-19 Clinical Research Studies · Medicine · Parvovirus B19 Infection Studies · SARS-CoV-2 and COVID-19 Research · Internal Medicine · Pediatrics · Virology
| Highly cited | No |
|---|