Exploring the Surge in Paediatric Type 2 Diabetes in an Inner-City London Centre—A Decade-Long Analysis of Incidence, Outcomes, and Transition
Bibliographic Data
| ID | 15717887 |
|---|---|
| Authors | Farah Abdelhameed (0000-0001-5572-1233, Barts Health NHS Trust), A M Giuffrida (Barts Health NHS Trust), Anna Giuffrida (Barts Health NHS Trust—Royal London Children’s Hospital, London E1 1BB, UK), Ben Thorp (Barts Health NHS Trust), Myuri Moorthy (Barts Health NHS Trust), Myuri K Moorthy (Barts Health NHS Trust—Royal London Children’s Hospital, London E1 1BB, UK), Evelien Gevers (0000-0002-4397-4126, Barts Health NHS Trust, corresponding author) |
| Year | 2024 |
| Volume | 11 |
| Issue | 2 |
| Pages | 173-173 |
| Publication date | 2024-01-29 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children11020173 |
| PMID | 38397285 |
| OpenAlex | W4391324303 |
| Language | EN |
| References cited | 43 |
The rising prevalence of paediatric type 2 diabetes (T2D) is concerning, particularly with limited medical intervention despite evidence of accelerated disease progression. This study of a Barts Health NHS Trust cohort from 2008 to 2022 aims to elucidate the incidence, clinical outcomes, and complications associated with paediatric T2D. A retrospective analysis utilising electronic and paper records identified 40 patients with T2D. The incidence doubled from 2.6/year in 2008-2013 to 5.4/year in 2014-2018. Sixty-eight percent exhibited co-morbidities, notably learning disabilities. At diagnosis, the mean BMI was 32.4 ± 6.71 kg/m 2 , with no gender-based disparity and no significant change over a two-year follow-up. The initial HbA1c was 75.2 ± 21.0 mmol/mol, decreasing to 55.0 ± 17.4 mmol/mol after three months ( p = 0.001) and then rising to 63.0 ± 25.5 mmol/mol at one year ( p = 0.07). While 22/37 patients achieved HbA1c p = 0.34). This study highlights substantial therapeutic failure, with current management falling short in achieving a sustained reduction in BMI or HbA1c. Novel treatment approaches are needed to improve clinical outcomes and address the high burden of co-morbidities and complications
Cohort · Diabetes mellitus · Incidence (geometry · Medical record · Retrospective cohort study · Type 2 diabetes · Diabetes and associated disorders · Diabetes Management and Research · Diabetes Treatment and Management · Medicine · Endocrinology · Internal Medicine · Pediatrics
| Highly cited | No |
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