Body Mass Trajectory Affects the Long-Term Occurrence of Metabolic Syndrome in Adult Patients with Severe Obesity

Bibliographic Data

ID15718196
AuthorsJuliette Hazart (0000-0001-8720-9373, Université Clermont Auvergne), Florence Montel (Université Clermont Auvergne), E Gentes (0000-0002-8915-5652, Université Clermont Auvergne), Clément Lahaye (Université Clermont Auvergne), Mélanie Pouget (0000-0002-3972-0262, Université Clermont Auvergne), N Farigon (Université Clermont Auvergne), M Miolanne (Université Clermont Auvergne), Aurélien Mulliez (0000-0002-9080-0444, Genetique Reproduction and Developpement), Yves Boirie (0000-0002-3999-1599, Université Clermont Auvergne, corresponding author)
Year2022
Volume10
Issue1
Pages27-27
Publication date2022-12-23
Open AccessYes
TypeARTICLE
VenueChildren (JOURNAL)
Journal identifiersISSN: 2227-9067 • E-ISSN: 2227-9067
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/children10010027
PMID36670578
OpenAlexW4313260803
LanguageEN
Citations received1
References cited8

Independently of absolute BMI values, the amount, onset date, and duration of early body weight gain may influence cardio-metabolic health later in adulthood. Values of cardiac and metabolic variables from a cohort study of morbidly obese patients were retrospectively analyzed to study the association between early weight history and metabolic syndrome (MetS) occurrence in adults. Of 950 patients with severe morbid obesity (age 44.3 ± 13.8 y, BMI 42.5 ± 7.0 kg/m 2 ), 31.4% had started excess weight gain in childhood (CH), 19.9% in adolescence (ADO), and 48.7% in adulthood (AD). Despite different BMI values, MetS prevalence (57.8%) was not significantly different in the three groups (54.4% CH vs. 57.7% ADO vs. 59.8% AD, p = 0.59). The overweight onset period was not significantly associated with the development of MetS in adults (ADO: OR = 1.14 [0.69-1.92], p = 0.60; AD: OR = 0.99 [0.62-1.56], p = 0.95) despite a higher BMI in the early obesity onset group. Weight gain of more than 50% after age 18 years significantly increased the risk of MetS (OR = 1.75 [1.07-2.88], p = 0.026). In addition to crude BMI values, analysis of body mass trajectories is a relevant clinical tool in the assessment of metabolic risk, suggesting that the magnitude of weight gain may be more important for metabolic syndrome progression than the period of obesity onset

Body mass index · Body weight · Cohort · Cohort study · Metabolic syndrome · Obesity · Overweight · Weight gain · Young adult · Birth, Development, and Health · Cardiovascular Function and Risk Factors · Medicine · Obesity, Physical Activity, Diet · Endocrinology · Internal Medicine · Pediatrics

Tools

Open DOIOpen Access