Management of Central Precocious Puberty in Children with Hypothalamic Hamartoma
Bibliographic Data
| ID | 15718525 |
|---|---|
| Authors | Junghwan Suh (0000-0002-2092-2585, Yonsei University), Youngha Choi (0000-0002-1607-6048, Yonsei University), Jun Suk Oh (0000-0002-5765-2347, Yonsei University), Kyungchul Song (0000-0002-8497-5934, Yonsei University), Han Saem Choi (0000-0003-4140-0345, Yonsei University), Ahreum Kwon (0000-0002-9692-2135, Yonsei University), Hyun Wook Chae (0000-0001-5016-8539, Yonsei University), Ho-Seong Kim (0000-0003-1135-099X, Yonsei University, corresponding author) |
| Year | 2021 |
| Volume | 8 |
| Issue | 8 |
| Pages | 711-711 |
| Publication date | 2021-08-18 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children8080711 |
| PMID | 34438602 |
| OpenAlex | W3194018695 |
| Language | EN |
| References cited | 3 |
Hypothalamic hamartoma (HH) is a rare, congenital, and benign lesion of the tuber cinereum, typically presenting with central precocious puberty (CPP), gelastic seizure, and developmental delay. This study aimed to investigate CPP in HH patients and compare clinical features between before and after gonadotropin-releasing hormone (GnRH) agonist treatment. A total of 30 HH patients under 18 years of age who visited Severance Children's Hospital between January 2005 and May 2020 were retrospectively reviewed. Fourteen patients were male (46.7%) and sixteen (53.3%) were female, with a mean age at diagnosis was4.2 ± 2.9 years. During follow-up, 24 patients (80.0%) were diagnosed with CPP, 15 patients (50.0%) had gelastic seizure, and 13 patients (43.3%) had developmental delay. The gelastic seizure was significantly associated with sessile type HH rather than pedunculated type HH (85.7% vs. 18.8%, p = 0.001). After GnRH agonist treatment, discrepancies between bone age and chronological age decreased (3.3 ± 1.3 years to 2.0 ± 1.7 years, p = 0.002). Additionally, height standard deviation score for bone age was increased, and predicted adult height increased significantly in females, while males showed an increasing trend. Clinical symptoms of HH were closely associated with the location of HH, and GnRH agonist treatment was safe and effective in the management of CPP caused by HH
Agonist · Bone age · Central precocious puberty · Gelastic seizure · Gonadotropin-releasing hormone · Hamartoma · Hormone · Hypothalamic hamartoma · Luteinizing hormone · Pathology · Precocious puberty · Hedgehog Signaling Pathway Studies · Hypothalamic control of reproductive hormones · Medicine · Testicular diseases and treatments · Internal Medicine · Pediatrics
| Highly cited | No |
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