Atopy and Elevation of IgE, IgG3, and IgG4 May Be Risk Factors for Post Covid-19 Condition in Children and Adolescents

Bibliographic Data

ID15718587
AuthorsRobert Walter Körner (0000-0003-3164-4952, University Hospital Cologne, corresponding author), Ole Yannick Bansemir (University Hospital Cologne), Rosa Franke (Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany), Julius Sturm (University of Cologne), Hormos Salimi Dafsari (0000-0003-3483-5009, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases)
Year2023
Volume10
Issue10
Pages1598-1598
Publication date2023-09-25
Open AccessYes
TypeARTICLE
VenueChildren (JOURNAL)
Journal identifiersISSN: 2227-9067 • E-ISSN: 2227-9067
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/children10101598
PMID37892261
OpenAlexW4387019389
LanguageEN
Citations received1
References cited45

SARS-CoV-2 infection causes transient cardiorespiratory and neurological disorders, and severe acute illness is rare among children. Post COVID-19 condition (PCC) may cause profound, persistent phenotypes with increasing prevalence. Its manifestation and risk factors remain elusive. In this monocentric study, we hypothesized that atopy, the tendency to produce an exaggerated immunoglobulin E (IgE) immune response, is a risk factor for the manifestation of pediatric PCC. We present a patient cohort (n = 28) from an early pandemic period (2021-2022) with comprehensive evaluations of phenotypes, pulmonary function, and molecular investigations. PCC predominantly affected adolescents and presented with fatigue, dyspnea, and post-exertional malaise. Sensitizations to aeroallergens were found in 93% of cases. We observed elevated IgE levels (mean 174.2 kU/L, reference p p < 0.05). A total of 57% of patients showed self-limiting disease courses with mean recovery at 12.7 months (range 5-25 months), 29% at 19.2 months (range 12-30 months), and the rest demonstrated overall improvement. These findings offer additional insights into immune dysregulation as a risk factor for pediatric PCC

Antibody · Asthma · Asymptomatic · Atopy · Cohort · Immune dysregulation · Immune system · Immunoglobulin E · Malaise · Risk factor · Sibling · Autoimmune and Inflammatory Disorders Research · Fibromyalgia and Chronic Fatigue Syndrome Research · Long-Term Effects of COVID-19 · Medicine · Immunology · Internal Medicine · Pediatrics

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