Body Adiposity Partially Mediates the Association between FTO rs9939609 and Lower Adiponectin Levels in Chilean Children
Bibliographic Data
| ID | 15718651 |
|---|---|
| Authors | Carolina Ochoa‐Rosales (0000-0001-8048-9165, Adolfo Ibáñez University), Lorena Mardones (0000-0001-8037-4296, Universidad Católica de la Santísima Concepción), Marcelo Villagran (0000-0003-3645-5659, Universidad Católica de la Santísima Concepción), Claudio Aguayo (0000-0003-1805-7737, University of Concepción), Miquel Martorell (0000-0003-3183-7623, University of Concepción), Carlos Celis-Morales (0000-0003-2612-3917, University of Glasgow), Natalia Ulloa (0000-0002-0437-5016, University of Concepción, corresponding author) |
| Year | 2023 |
| Volume | 10 |
| Issue | 3 |
| Pages | 426-426 |
| Publication date | 2023-02-22 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children10030426 |
| PMID | 36979984 |
| OpenAlex | W4321597884 |
| Language | EN |
| References cited | 55 |
Children carrying the minor allele 'A' at the fat mass and obesity-associated protein ( FTO) gene have higher obesity prevalence. We examined the link between FTO rs9939609 polymorphism and plasma adiponectin and the mediating role of body adiposity, in a cross-sectional study comprising 323 children aged 6-11 years. Adiponectin and FTO genotypes were assessed using a commercial kit and a real-time polymerase chain reaction with high-resolution melting analysis, respectively. Body adiposity included body mass index z-score, body fat percentage and waist-to-hip ratio. To investigate adiponectin (outcome) associations with FTO and adiposity, linear regressions were implemented in additive models and across genotype categories, adjusting for sex, age and Tanner's stage. Using mediation analysis, we determined the proportion of the association adiponectin- FTO mediated by body adiposity. Lower adiponectin concentrations were associated with one additional risk allele (β additive = -0.075 log-μg/mL [-0.124; -0.025]), a homozygous risk genotype (β AA/TT = -0.150 [-0.253; -0.048]) and a higher body mass index z-score (β = -0.130 [-0.176; -0.085]). Similar results were obtained for body fat percentage and waist-to-hip ratio. Body adiposity may mediate up to 29.8% of the FTO -adiponectin association. In conclusion, FTO rs9939609-related differences in body adiposity may partially explain lower adiponectin concentrations. Further studies need to disentangle the biological pathways independent from body adiposity
Adiponectin · Body adiposity index · Body Fat Percentage · Body mass index · Classification of obesity · Fat mass · Insulin resistance · Obesity · Waist · Waist–hip ratio · Adipokines, Inflammation, and Metabolic Diseases · Adipose Tissue and Metabolism · Cardiovascular Disease and Adiposity · Medicine · Endocrinology · Internal Medicine
| Highly cited | No |
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