Familial and Genetic Influences on the Common Pediatric Primary Pain Disorders
A Twin Family Study
Bibliographic Data
| ID | 15718683 |
|---|---|
| Authors | G David Champion (0000-0003-4557-262X, UNSW Sydney, corresponding author), Minh Bui (0000-0002-9099-6870, The University of Melbourne), Aneeka Bott (Sydney Children's Hospital), Theresa Donnelly (0000-0002-5943-428X, Sydney Children's Hospital), Shuxiang Goh (0000-0003-1753-5872, Sydney Children's Hospital), Cindy Chapman (Sydney Children's Hospital), Daniel A Lemberg (0000-0002-8583-0956, Sydney Children's Hospital), Daniel Lemberg (Sydney Children's Hospital), Tiina Jaaniste (0000-0002-1573-7844, UNSW Sydney), John L Hopper (0000-0002-8567-173X, The University of Melbourne), John Hopper (The University of Melbourne) |
| Year | 2021 |
| Volume | 8 |
| Issue | 2 |
| Pages | 89-89 |
| Publication date | 2021-01-28 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children8020089 |
| OpenAlex | W3126430481 |
| Language | EN |
| Citations received | 3 |
| References cited | 70 |
The primary pain disorders of childhood are highly prevalent but have infrequently been studied collectively. Genetic influences have been suggested to be causally implicated. Surveys were sent to 3909 Australian twin families, assessing the lifetime prevalence of growing pains, migraine, headache, recurrent abdominal pain, low back pain, and persistent pain (not otherwise specified) in pediatric twins and their immediate family members. Comparisons between monozygous (MZ) and dizygous (DZ) twin pair correlations, concordances and odds ratios were performed to assess the contribution of additive genetic influences. Random-effects logistic regression modelling was used to evaluate relationships between twin individuals and their co-twins, mothers, fathers and oldest siblings with the subject conditions. Twin analyses of responses from 1016 families revealed significant influence of additive genetic effects on the presence of growing pains, migraine, and recurrent abdominal pain. The analyses for headache, low back pain, and persistent pain overall did not conclusively demonstrate that genetic influences were implicated more than shared environmental factors. Regression analyses demonstrated varying levels of significance in relationships between family members and twin individuals for the tested conditions, with strongest support for genetic influences in growing pains and migraine. These data, together with previously published association analyses, suggest common causal influences including genes
Biology · Environmental health · Family aggregation · Heritability · Logistic regression · Migraine · Odds · Odds ratio · Population · Psychiatry · Twin study · Gastroesophageal reflux and treatments · Medicine · Musculoskeletal pain and rehabilitation · Pediatric Pain Management Techniques · Psychology · Genetics · Internal Medicine
| Citations per year | 1 |
|---|---|
| Citation span | 2023 - 2026 (4) |
| Highly cited | No |