Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli
A Pilot Dynamic Study
Bibliographic Data
| ID | 15718815 |
|---|---|
| Authors | Styliani Geronikolou (0000-0003-1227-5274, National and Kapodistrian University of Athens, corresponding author), Vasilis Vasdekis (Athens University of Economics and Business), Aimilia Mantzou (0000-0001-6606-8647, National and Kapodistrian University of Athens), Constantinos H Davos (0000-0002-0321-7569, Academy of Athens), Dennis V Cokkinos (0000-0002-3390-4191, Academy of Athens), George P Chrousos (0000-0002-3098-5264, National and Kapodistrian University of Athens) |
| Year | 2023 |
| Volume | 10 |
| Issue | 2 |
| Pages | 248-248 |
| Publication date | 2023-01-30 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children10020248 |
| PMID | 36832376 |
| OpenAlex | W4318479431 |
| Language | EN |
| References cited | 49 |
This pilot repeated measures study aims to evaluate the dynamics of the autonomic nervous system (ANS), the hypothalamic-pituitary-adrenal (HPA) axis, and/or their interplay with low-level inflammation in healthy schoolchildren during consecutive extrinsic stimuli. Twenty healthy schoolchildren and adolescents aged 11-14 years (12.5 ± 1.5) were consecutively exposed to an oral task (#2) and an arithmetic task (#3) (Trier Social Stress Test for Children (TSST-C)), lasting 5 min each, and a three-minute cellular phone call (#4). Salivary cortisol (SC) was sampled at baseline (#1) and immediately after each exposure (#2, 3, and 4). Baseline serum high-sensitivity C-reactive protein (hsCRP) and cortisol levels were also assessed. ANS dynamics and complexity were measured using Sample Entropy (SampEn) at each experimental time period (#1-4). Baseline serum hCRP and cortisol correlated negatively to each other, while the ANS and HPA axis acute reactions to the three consecutive stimuli differed over time. The ANS adaptation to these stimuli included complexity modulation, which was not dependent on baseline hsCRP or cortisol, and weakened during the third stimulation. However, baseline hsCRP and cortisol had a weakening and an increasing effect on the HPA axis over time, respectively. We conclude that low-level inflammation and baseline morning cortisol level have no effect on ANS dynamics but influence the HPA axis response to consecutive external stimuli
Audiology · Biology · Cortisol awakening response · Fight-or-flight response · Hormone · Hydrocortisone · Hypothalamic–pituitary–adrenal axis · Morning · Sample entropy · Stimulation · Summation · Trier social stress test · Heart Rate Variability and Autonomic Control · Medicine · Neuroendocrine regulation and behavior · Psychology · Stress Responses and Cortisol · Endocrinology · Internal Medicine
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| Highly cited | No |
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