Interleukin-2 Receptor as a Marker of Oxidative Stress in Paediatric Patients with Chronic Kidney Disease or Hypertension
Bibliographic Data
| ID | 15718975 |
|---|---|
| Authors | Nataša Marčun Varda (0000-0003-0634-3576, University Clinical Centre Maribor, corresponding author), Mirjam Močnik (0000-0002-0300-6753, University Clinical Centre Maribor), Martina Filipič (University Clinical Centre Maribor), Evgenija Homšak (0000-0003-3904-1814, University Clinical Centre Maribor), Mateja Svetej (University Clinical Centre Maribor), Sonja Golob Jančič (0000-0002-6201-7321, University Clinical Centre Maribor) |
| Year | 2025 |
| Volume | 12 |
| Issue | 5 |
| Pages | 569-569 |
| Publication date | 2025-04-28 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children12050569 |
| PMID | 40426748 |
| OpenAlex | W4410008007 |
| Language | EN |
| References cited | 42 |
Background/Objectives : Oxidative stress and systemic inflammation are significant contributors to the development and progression of cardiovascular disease, causing adverse effects on vascular health and atherosclerosis from an early age. Patients with established cardiovascular risk factors commonly exhibit markers indicating heightened oxidative stress and inflammation. Our study sought to assess the levels of interleukin-2 receptor, which could serve as an early indicator of cardiovascular damage due to oxidative stress and inflammation in at-risk children. Methods : The study comprised 46 paediatric patients with chronic kidney disease, 50 paediatric patients with hypertension, and 33 healthy controls. Anthropometric measurements, pulse wave velocity, body composition, routine laboratory tests, and measurements of interleukin-2 receptor levels were conducted for all participants. Results : Interleukin-2 receptor levels were notably lower in patients with hypertension ( p p Conclusions : Children diagnosed with hypertension or obesity exhibited notably lower interleukin-2 receptor levels
Disease · Kidney disease · Oxidative stress · Apelin-related biomedical research · Hormonal Regulation and Hypertension · Medicine · Sodium Intake and Health · Gastroenterology · Internal Medicine
| Highly cited | No |
|---|