Assessment of Phoenix Sepsis Score, pSofa, Pelod-2, and PRISM III in Pediatric Intensive Care
Bibliographic Data
| ID | 15719160 |
|---|---|
| Authors | Adriana Hadzhieva-Hristova (0000-0003-3036-1918, Medical University of Varna, corresponding author), Darina Krumova (Medical University of Varna), Temenuga Stoeva (0000-0001-6202-4532, Medical University of Varna), Ralitza Georgieva (Medical University of Sofia), Violeta Iotova (0000-0003-4160-1200, Medical University of Varna) |
| Year | 2025 |
| Volume | 12 |
| Issue | 3 |
| Pages | 262-262 |
| Publication date | 2025-02-21 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children12030262 |
| PMID | 40150545 |
| OpenAlex | W4407812496 |
| Language | EN |
| References cited | 26 |
Background/Objectives : Early identification of pediatric sepsis complications in intensive care is challenging and requires improved diagnostic tools. This study aimed to compare the Phoenix Sepsis Score (PSS), pSOFA, PELOD-2, and PRISM III in assessing clinical complexity in children with septic and critical conditions in the PICU and to identify the most suitable scale for this patient cohort. Methods : Data were collected prospectively from 53 children between June 2022 and January 2024. Patients were categorized into septic (n = 42) and non-infectious SIRS (n = 11) and further classified by outcome-with/without complications (n = 23/30). The predictive accuracy of the scoring systems was evaluated by discrimination and calibration and by recalibration for the PSS for improved performance. Results : Respiratory (18.8%) and neurological complications (9.4%) were the most common adverse events. Clinical deterioration was observed in 43.4% of cases, including one fatality. Patients with complications stayed longer in the PICU (14 ± 10 days). In the patients with complications, all scoring systems had higher median values. Only PSS showed a significant difference ( p = 0.0023). PSS demonstrated the highest overall predictive accuracy (76.2%) outperforming PRISM III (62.3%) and PELOD-2 (58.5%). The pSOFA scale showed high accuracy (88.0%) in identifying patients without complications. The strongest association was between chronic disease (hazard ratio Exp(B) = 1.718) and deteriorations, while mechanical ventilation suggested a reduced risk of complications (Exp(B) = 0.509). Conclusions : PSS showed superior predictive accuracy (76.2%) for deteriorations in pediatric patients with suspected infection and proved adaptable for further validation in larger populations
Cohort · Intensive care · Intensive care medicine · Mechanical ventilation · Prospective cohort study · Sepsis · Septic shock · Disaster Response and Management · Medicine · Neonatal and Maternal Infections · Sepsis Diagnosis and Treatment · Emergency Medicine · Internal Medicine · Pediatrics
| Highly cited | No |
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