Investigating the Association between Serum and Hematological Biomarkers and Neonatal Sepsis in Newborns with Premature Rupture of Membranes

(1) Background: Neonatal early-onset sepsis (EOS) is associated with important mortality and morbidity. The aims of this study were to evaluate the association between serum and hematological biomarkers with early onset neonatal sepsis in a cohort of patients with prolonged rupture of membranes (PROM) and to calculate their diagnostic accuracy. (2) Methods: A retrospective cohort study was conducted on 1355 newborns with PROM admitted between January 2017 and March 2020, who were divided into two groups: group A, with PROM ≥ 18 h, and group B, with ROM p = 0.005) and third day ( p = 0.028), and high C-reactive protein (CRP) values from the first day ( p = 0.004). Procalcitonin (area under the curve-AUC = 0.78) and CRP (AUC = 0.76) measured on the first day had the best predictive performance for early-onset neonatal sepsis. (4) Conclusions: Our results outline the feasibility of using procalcitonin and CRP measured on the first day taken individually in order to increase the detection rate of early-onset neonatal sepsis, in the absence of positive blood culture

C-reactive protein · Inflammation · Neonatal sepsis · Obstetrics · Procalcitonin · Prom · Retrospective cohort study · Sepsis · White blood cell · Medicine · Neonatal and Maternal Infections · Sepsis Diagnosis and Treatment · Streptococcal Infections and Treatments · Gastroenterology · Internal Medicine · Pediatrics

• Predictive Value of CRIB II Score, Hematological Markers and Maternal-Fetal Risk Factors for Mortality in Neonatal Sepsis

  Open Access•Bugis Mardina Lubis, Cindy Clarissa Sirait et al.•Children•2025

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