Postnatally Acquired Neonatal CMV Infection in Preterm Infants
From a Case Series to a Narrative Review of the Literature
Bibliographic Data
| ID | 15720054 |
|---|---|
| Authors | Serena Salomè (0000-0001-6014-9374, University of Naples Federico II), Ida D’Acunzo (Federico II University Hospital), Clara Coppola (0000-0003-3588-3846, Federico II University Hospital), Giovanna Montesano (0000-0001-7671-5780, Federico II University Hospital), Gaetano Ausanio (Ospedale Sant'Anna), Angela Umbaldo (Federico II University Hospital), Fiorella Migliaro (Federico II University Hospital), Letizia Capasso (0000-0002-0373-9201, Federico II University Hospital), Francesco Raimondi (University of Naples Federico II) |
| Year | 2025 |
| Volume | 13 |
| Issue | 1 |
| Pages | 46-46 |
| Publication date | 2025-12-29 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children13010046 |
| PMID | 41597054 |
| OpenAlex | W7117750531 |
| Language | EN |
| References cited | 108 |
Background: Postnatal cytomegalovirus (pCMV) infection is a frequent viral condition in early infancy and is primarily acquired through maternal breastfeeding. Although usually asymptomatic in term infants, it can lead to significant morbidity in preterm neonates (gestational age Objectives: To describe a series of cases of pCMV infection and review the current evidence on its epidemiology, clinical manifestations, outcomes, and therapeutic management, aiming to identify gaps in knowledge and propose opportunities for improving the care of preterm infants. Methods: We analyzed clinical presentations of pCMV disease in a case series of preterm infants and reported cases and reviewed the recent literature regarding diagnostic approaches, antiviral therapy, and strategies for breastmilk management. Results: Current data highlight substantial variability in clinical management and outcomes. The lack of consensus on antiviral indications and treatment duration reflects a limited understanding of the disease's natural history. Approaches to breastmilk handling differ widely among centers and countries, further complicating the standardization of care. Conclusions: pCMV infection remains a relevant yet under-recognized condition in neonatal medicine. Improved diagnostic strategies, clearer therapeutic guidelines, and harmonized recommendations for breastmilk management are needed to optimize the care of preterm infants at risk of or affected by pCMV disease
Asymptomatic · Cytomegalovirus · Disease · MEDLINE · Narrative review · Natural history · Pregnancy · Review article · Cytomegalovirus and herpesvirus research · Neonatal Health and Biochemistry · Parvovirus B19 Infection Studies
| Highly cited | No |
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