Effective role of vitamin D and omega-3 on rats with induced Crohn’s disease
Bibliographic Data
| ID | 15792125 |
|---|---|
| Authors | Naeem M Rabeh (Helwan University, corresponding author), Hoda S Ibrahim (Helwan University), Fatma N Osman (Helwan University) |
| Year | 2022 |
| Pages | 65-76 |
| Publication date | 2022-07-06 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Health Sciences (JOURNAL) |
| Journal identifiers | ISSN: 2550-696X • E-ISSN: 2550-6978 |
| Publisher | Universidad Tecnica de Manabi (PUBLISHER • EC) |
| DOI | 10.53730/ijhs.v6ns8.10400 |
| OpenAlex | W4289531386 |
| Language | EN |
| References cited | 1 |
Crohn's disease is an irreversible inflammatory disease, mainly affecting the gastrointestinal tract. The aim of present study was to investigate the effect of dietary vitamin D and omega 3 supplementation on rats with induced Crohn’s disease. Twenty – four adult male albino rats weighing (160 gm) were divided into 4 groups. The 1st group (n=6) was fed on the basal diet. The 2nd to 4th of rats (n=18) were injected with (10 mg/kg for 3 days) of indomethacin at the end of the experiment to induce Crohn’s disease. Groups (3 and 4) were fed on basal diet and given orally 1000/IU/kg/ b.w. of vitamin D and 600 mg/kg/b.w. of omega 3 respectively. At the end of the experimental period (8 weeks), rats were scarified. Biochemical analysis of the tested parameters was determined. The Results indicated that indomethacin Crohn’s rats showed a significant (P< 0.05) decrease in serum albumin, serum Catalase and serum Glutathione peroxidase compared to the negative control one, while serum liver function, MDA, CRP, and immunity proteins were significantly increased
Albumin · Antioxidant · Basal (medicine · Catalase · Crohn's disease · Disease · Glutathione peroxidase · Oxidative stress · Vitamin E · Chemistry · Inflammatory Bowel Disease · Medicine · Vitamin C and Antioxidants Research · Vitamin D Research Studies · Biochemistry · Endocrinology · Internal Medicine
| Highly cited | No |
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