Comparative Study of Haemodynamic Responses of Butorphanol and Fentanyl While Surgeries

Background: In spite of several new airway devices emerging in recent times, direct laryngoscopy and endotracheal intubation still reigns as the gold standard in airway management, Butorphanol is a morphinan chemically related to levorphanol and has mixed agonist-antagonist properties. It is more potent and it has advantage of producing less addiction and respiratory depression. Fentanyl is μ, receptor agonist, structurally related to phenylpiperidines having clinical potency ratio 50 – 100 times of morphine. It is more potent. Butorphanol tartarate is a totally synthetic narcotic antagonist analgesic, which does not require opium alkaloids for its synthesis. Aim and objectives: Comparing the haemodynamic parameters (pulse, SBP, DBP, MAP, SpO2) during general anaesthesia in patients receiving butorphanol and fentanyl. Material and Methods: This is a double-blind randomised study comparing the two opioids, fentanyl and butorphanol, was carried out in Muzaffarnagar Medical College & Hospital, Muzaffarnagar, Uttar Pradesh, India. In our study 62 cases were divided randomly into two groups. Group A patients received inj .butorphanol tartarate and Group B patients received inj fentanyl citrate. The complete data was recorded by a single observer regarding haemodynamic parameters (systolic blood pressure, diastolic blood pressure, heart rate etc.) intraoperatively as well as postoperatively

Analgesic · Anesthesia · Blood pressure · Butorphanol · Fentanyl · Hemodynamics · Morphine · Opioid · Airway Management and Intubation Techniques · Anesthesia and Sedative Agents · Medicine · Veterinary Pharmacology and Anesthesia · Internal Medicine