Optimization of gel formula from active fraction of manggost fruit (Garcinia mangostana. L) and antibacterial activity test against Staphylococcus epidermidis

Bibliographic Data

ID15799113
AuthorsAndreas Hiba Mayorga (Universitas Setia Budi, corresponding author), Ilham Kuncahyo (0000-0003-4075-693X, Universitas Setia Budi), Opstaria Saptarini (0000-0002-6159-3001, Universitas Setia Budi)
Year2025
Volume9
IssueS1
Pages120-160
Publication date2025-02-27
Open AccessYes
TypeARTICLE
VenueInternational Journal of Health Sciences (JOURNAL)
Journal identifiersISSN: 2550-696X • E-ISSN: 2550-6978
PublisherUniversidad Tecnica de Manabi (PUBLISHER • EC)
DOI10.53730/ijhs.v9ns1.15577
OpenAlexW4407995367
LanguageEN
References cited17

The purpose of this study was to determine the antibacterial activity of the ethyl acetate fraction of mangosteen peel and the effect of the combination of Carbopol, HPMC, and Propylene glycol as humectants on physical properties and antibacterial activity. The results of the fractionation of the extract were tested on Staphylococcus epidermidis bacteria using the diffusion method, the ethyl acetate fraction which had antibacterial activity with a concentration of 10% was made into a gel preparation with the composition of carbopol, HPMC, propylene glycol with run 14 obtained by the Simplex Latice Design method. The physical quality test of the preparation was carried out, namely organoleptic test, homogeneity, pH, adhesion, spreadability, viscosity, and antibacterial activity. Test data for physical quality and antibacterial activity analyzed using the Simplex Latice Design method, after which the analyzed using the Simplex Latice Design, and statistics using SPSS with the One Way Anova test. The results of the study stated that the ethyl acetate fraction of mangosteen peel can be made into mangosteen peel gel preparations for concentrations of Carbopol 94 1.5 g, HPMC 1000DB 2.5 g, propylene glycol 5 g with a spreadability value of 4.35 cm, viscosity 433.33, antibacterial 21, 4mm

Antibacterial activity · Bacteria · Biology · Chromatography · Fraction (chemistry · Garcinia mangostana · Staphylococcus aureus · Staphylococcus epidermidis · Traditional medicine · Chemistry · Medicine · Natural Compound Pharmacology Studies · Psidium guajava Extracts and Applications · Traditional and Medicinal Uses of Annonaceae · Food Science

Tools

Open DOIOpen Access