Analysis of the ZNT8, GAD65, HLA-DQA1, HLA-DQB1, and C-peptides in Indonesian children with type 1 diabetes mellitus
Bibliographic Data
| ID | 15799324 |
|---|---|
| Authors | Nur Rochmah (0000-0002-9626-9615, Airlangga University, corresponding author), Muhammad Faizi (0000-0002-7009-4896, Airlangga University, corresponding author), Yuni Hisbiyah (0000-0002-1362-108X, Airlangga University, corresponding author), Rayi Kurnia Perwitasari (0000-0002-8699-4063, Airlangga University, corresponding author), Tyas Maslakhatien Nuzula (0000-0002-7806-4501, Airlangga University, corresponding author), Anang Endaryanto (0000-0002-7988-2274, Airlangga University, corresponding author), Soetjipto Soetjipto (Airlangga University, corresponding author) |
| Year | 2022 |
| Pages | 1927-1936 |
| Publication date | 2022-09-19 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Health Sciences (JOURNAL) |
| Journal identifiers | ISSN: 2550-696X • E-ISSN: 2550-6978 |
| Publisher | Universidad Tecnica de Manabi (PUBLISHER • EC) |
| DOI | 10.53730/ijhs.v6ns9.12857 |
| OpenAlex | W4296456036 |
| Language | EN |
| References cited | 1 |
Autoimmune reaction in Type 1 Diabetes Mellitus (T1DM) is caused by genetic and environmental factors. The genes HLA-DQA1 and HLA-DQB1 are strongly associated with T1DM. Other established markers of T1DM were Zinc Transporter 8 Antibody (ZnT8), Glutamic Acid Decarboxylase Antibody-65 (GAD65), and C-peptide. This study aims to analyze ZnT8, GAD65, HLA-DQA1, HLA-DQB1, and C-peptide in Indonesian children with T1DM. A cross-sectional study of T1DM children was conducted in Dr. Soetomo Hospital, Indonesia. ZnT8, GAD65, HLA-DQA1, HLA-DQB1, and C-peptide were examined with an ELISA kit. Mann-Whitney test was performed with a significant value of p<0.05. A total of 62 participants consisting of 31 children for each group were enrolled. The prevalence of ZnT8, GAD65, and C-peptide in T1DM patients was 77.4%, 90.3%, and 87.1%. There are 74% of T1DM children had two positive antibodies and 55% had two positive HLA peptides. There was no difference in HLA-DQA1 and HLA-DQB1 peptides between T1DM and control groups (p=0.12; p=0.19). Meanwhile, the comparison between ZnT8, GAD65, and C-Peptide values between T1DM and control groups shows a significant difference (p<0.05). HLA-DQA1 peptide value was higher in T1DM children and HLA-DQB1 peptide value was higher in non-T1DM children
Allele · Antibody · Antigen · Biology · C-peptide · Diabetes mellitus · Gene · HLA-DQ · Human leukocyte antigen · Insulin · Type 1 diabetes · Diabetes and associated disorders · Digestive system and related health · Medicine · Pancreatic function and diabetes · Biochemistry · Endocrinology · Immunology · Internal Medicine
| Highly cited | No |
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