Pharmaceutical development of metronidazole loaded transferosome gel for skin delivery
Bibliographic Data
| ID | 15799439 |
|---|---|
| Authors | H Gayathri (SRM Institute of Science and Technology, corresponding author), S Sangeetha (SRM Institute of Science and Technology, corresponding author) |
| Year | 2022 |
| Pages | 2258-2274 |
| Publication date | 2022-08-18 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Health Sciences (JOURNAL) |
| Journal identifiers | ISSN: 2550-696X • E-ISSN: 2550-6978 |
| Publisher | Universidad Tecnica de Manabi (PUBLISHER • EC) |
| DOI | 10.53730/ijhs.v6ns7.11848 |
| OpenAlex | W4292616362 |
| Language | EN |
| References cited | 1 |
Objective: The focus of this research was out whether a transfersomal gel formulation for transdermal delivery of Metronidazole. Methods: Azole Antifungals include metronidazole, which is used to treat fungal and yeast infections. Transferosomes are supra-molecular aggregates that are ultra-flexible and have a high ability to penetrate mammalian skin intact. Drug encapsulation in various transfersomal formulations containing various ratios of different drug concentrations (0.05, 0.1, 0.2, 0.3, 0.4, 0.5 g) and Carbopol-934 (0.5, 1, 2 g) is being researched for use as a transferosomal gel.Results: Entrapment efficiency (EE %), drug content, in-vitro skin permeation tests, and stability investigations were performed on the produced formulations. The vesicles were spherical in shape, as confirmed by Transmission Electron Microscopy. Metronidazole was successfully pinned with a standardised drug content in all formulations, according to the resultsThe 0.1 g Metronidazole optimised transferosome formulation MG2 showed promising results, with maximum drug release (94.32%) and maximum drug release (94.32%). Conclusion: According to this report, transferosomes are a promising long-term delivery mechanism for metronidazole and have reasonably good stability.This study suggests that transferosomes containing Metronidazole may be used as a transdermal drug delivery tool for fungal skin infections
Antibiotics · Chromatography · Drug · Drug delivery · Metronidazole · Transdermal · Advanced Drug Delivery Systems · Advancements in Transdermal Drug Delivery · Chemistry · Medicine · Transgenic Plants and Applications · Biochemistry · Pharmacology
| Highly cited | No |
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