Comparison of selenium and deiodinase enzyme among healthy controls and hypothyroid patients
A pilot study
Bibliographic Data
| ID | 15799555 |
|---|---|
| Authors | Priya K Dhas (0000-0002-8900-4360, Vinayaka Missions University, corresponding author), G Ramani (Vinayaka Missions University) |
| Year | 2022 |
| Pages | 6095-6103 |
| Publication date | 2022-04-26 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Health Sciences (JOURNAL) |
| Journal identifiers | ISSN: 2550-696X • E-ISSN: 2550-6978 |
| Publisher | Universidad Tecnica de Manabi (PUBLISHER • EC) |
| DOI | 10.53730/ijhs.v6ns1.6066 |
| OpenAlex | W4224439104 |
| Language | EN |
| References cited | 1 |
Background: Selenium an essential trace element plays an important role in human growth and development. Selenoproteins are involved in thyroid hormone metabolism and recent reports suggest there is increasing prevalence of subclinical hypothyroidism when compared to hypothyroidism. Objectives: In this paper, we aimed to analyse whether the altered thyroid profile observed in subclinical hypothyroidism is due to the deficiency of selenium or due to the defect in activity of deiodinase enzyme involved in thyroid hormone metabolism. Materials and methods: The study included the patients attending the outpatient department of General Medicine of VMKV Medical College and Hospitals, Salem. The study participants were classified into 3 groups based on their thyroid profile as Group 1- Control (n=20), Group 2: Patients with Subclinical hypothyroidism (n=20), Group 3: Patients with hypothyroidism (n=20). After obtaining informed consent from the study participants, blood sample was collected for Selenium and deiodinase assay. Selenium was performed in mass spectrophotometer using whole blood and deiodinase activity was measured in serum by ELISA method. Result: Our results showed a normal but statistically significant difference in the level of selenium and activity of deiodinase 2 enzyme in subclinical hypothyroidism and hypothyroidism when compared to healthy controls
Body mass index · Catalase · Deiodinase · DIO2 · Glutathione peroxidase · Hormone · Iodothyronine deiodinase · Outpatient clinic · Oxidative stress · Selenium · Selenium deficiency · Subclinical infection · Thyroid · Thyroid hormones · Birth, Development, and Health · Chemistry · Human Health and Disease · Medicine · Selenium in Biological Systems · Endocrinology · Internal Medicine
| Highly cited | No |
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