Evaluation of salivary alkaline phosphatase levels in tobacco users to determine its role as biomarker in oral potentially malignant disorders
Bibliographic Data
| ID | 15799604 |
|---|---|
| Authors | Pratiksha Kumar (Government Dental College and Hospital, corresponding author), Iram Ansari (corresponding author), Triveni Bhargava (corresponding author), Sumanta Kumar Kolay (Darbhanga Medical College and Hospital, corresponding author), Anuradha Agrawal (0000-0003-1499-8572, corresponding author), Anurag Bhargava (0000-0001-7187-8759, Manubhai Patel Dental College and Hospital, corresponding author) |
| Year | 2022 |
| Pages | 12148-12155 |
| Publication date | 2022-06-24 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Health Sciences (JOURNAL) |
| Journal identifiers | ISSN: 2550-696X • E-ISSN: 2550-6978 |
| Publisher | Universidad Tecnica de Manabi (PUBLISHER • EC) |
| DOI | 10.53730/ijhs.v6ns3.9610 |
| OpenAlex | W4286276715 |
| Language | EN |
| References cited | 2 |
Background: Although elevated salivary alkaline phosphatase (S-ALP) levels have been seen in oral squamous cell carcinoma, the status of S-ALP in cigarette users and those with oral potentially malignant disorders (OPMDs) is less well understood. The study's goals and objectives were to assess and compare S-ALP levels in tobacco users, nonusers, and people with OPMD. Materials and Methods: The study included 150 people who were divided into four groups: those who did not use tobacco, tobacco smokers, those who are in habit of tobacco chewing, and those who are in the habit of tobacco chewing/smoking and had a lesion. unstimulated saliva (5 mL) was collected and centrifuged for 15 minutes at 3000 rpm, and the supernatant was separated. In an automatic analyzer, S-ALP was calculated in the supernatant using the kinetic photometric method. Results: The information gathered was subjected to statistical analysis. S-ALP levels were 17.90 IU/L in healthy people who didn't smoke, 4.58 IU/L in smokers who didn't have a lesion, and 7.52 IU/L in tobacco chewers who didn't have a lesion, and 64.92 IU/L in people with OPMD. Using Kruskal–Wallis' ANOVA, the mean difference between the groups was statistically significant (P 0.001)
Alkaline phosphatase · Analysis of variance · Basal cell · Biomarker · Cancer · Chewing tobacco · Environmental health · Enzyme · Lesion · Pathology · Saliva · Tobacco smoke · Chemistry · Dentistry · Medicine · Mesenchymal stem cell research · Oral health in cancer treatment · Salivary Gland Disorders and Functions · Gastroenterology · Internal Medicine · Physiology
| Highly cited | No |
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