Assessment of some immune markers in typhoid-patients
A case control study
Bibliographic Data
| ID | 15801186 |
|---|---|
| Authors | Ali Reyadh Medhat (Middle Technical University, corresponding author), Ahmed Abduljabbar Jaloob Aljanabay (University of Kufa, corresponding author) |
| Year | 2022 |
| Pages | 4199-4210 |
| Publication date | 2022-04-11 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Health Sciences (JOURNAL) |
| Journal identifiers | ISSN: 2550-696X • E-ISSN: 2550-6978 |
| Publisher | Universidad Tecnica de Manabi (PUBLISHER • EC) |
| DOI | 10.53730/ijhs.v6ns1.5592 |
| OpenAlex | W4224132636 |
| Language | EN |
| Citations received | 5 |
| References cited | 2 |
A case-control study was carried out in the General Teaching Hospital in Balad City, Iraq. Eighty-eight male and female were included in this study; 58 typhoid-patients infected with S.typhi and 30 healthy individuals as controls. Acute typhoid-patients have been diagnosed according to positive blood culture and IgM and chronic typhoid-patients have been diagnosed according to positive stool culture and IgG. Four immunological markers have been measured in all individuals' serum; interleukin 4 (IL-4), interleukin 17 (IL-17), cluster of differentiation 8 (CD 8) and cluster of differentiation 22 (CD 22) using an Enzyme-Linked Immunosorbent Assay (ELISA). We diagnosed 32 and 26 patients infected with acute and chronic infection respectively, the results proved a significant increase (P-value=<0.05) in all markers in acute and chronic infections as compare with control. A significant differences P-value (0.0003 and <0.0001) has been proved between acute and chronic infection in IL-4 and IL-17 respectively. While, there was no significant differences P-value (0.13 and 0.32) between acute and chronic infection in CD8 and CD22 respectively. Conclusions: IL-4, IL-17, CD8 and CD22 serum levels increase in typhoid-patients caused by S.typhi in humans
Biology · CD8 · Immune system · Pathology · Salmonella typhi · Typhoid fever · Biomarkers in Disease Mechanisms · Cell death mechanisms and regulation · Kawasaki Disease and Coronary Complications · Medicine · Gastroenterology · Immunology · Internal Medicine
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| Citations per year | 1.25 |
|---|---|
| Citation span | 2022 - 2022 (1) |
| Highly cited | No |