The immune response in Covid-19 and its outcomes

Contribution of risk factors

Bibliographic Data

ID16893093
AuthorsPatrícia Maria Lourenço Dutra (0000-0002-2494-6912, Instituto Federal do Rio de Janeiro, corresponding author), Shayane Martins Rodrigues Gomes (0000-0002-4836-5725, Instituto Federal do Rio de Janeiro), Andréia Carolinne de Souza Brito (Instituto Federal do Rio de Janeiro), Rosiane Freire dos Santos (0000-0001-5085-5021, Instituto Federal do Rio de Janeiro), Ricardo Brandão De Oliveira (0000-0001-9355-6718, Instituto Federal do Rio de Janeiro), Juliana Pereira Borges (0000-0002-3581-7251, Instituto Federal do Rio de Janeiro), Joanna Reis Santos de Oliveira (Instituto Federal do Rio de Janeiro), Silvia Amaral Gonçalves da Silva, Silvia A G Da-Silva (0000-0003-1600-1238, Instituto Federal do Rio de Janeiro)
Year2024
Volume16
Issue6
Pagese4533
Publication date2024-06-18
Open AccessYes
TypeARTICLE
VenueCuadernos de Educación y Desarrollo (JOURNAL)
Journal identifiersISSN: 1989-4155 • E-ISSN: 1989-4155
PublisherBrazilian Journals (PUBLISHER)
DOI10.55905/cuadv16n6-116
OpenAlexW4399773981
LanguageEN
References cited115

The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in a global health crisis that has highlighted the importance of understanding the host immune response to viral infections. Although the immune system plays a crucial role in controlling viral replication and preventing serious disease, dysregulated immune responses can lead to severe tissue damage and multiple organ failure, as seen in severe cases of COVID-19. In this review, we discuss current knowledge of the immune response to SARS-CoV-2, focusing on the balance between protective and harmful immune responses. We describe the early innate immune response, including the role of interferons and inflammasomes, as well as the adaptive immune response. Furthermore, we discuss the mechanisms of immune dysregulation observed in severe cases of COVID-19, such as cytokine storm and autoimmunity. Finally, we highlight the importance of ongoing research into the host immune response to SARS-CoV-2 in developing effective treatments and vaccines. This article discusses the effects of the immune response to COVID-19 and how risk factors may impact these outcomes

2019-20 coronavirus outbreak · Disease · Immune system · Outbreak · COVID-19 Clinical Research Studies · COVID-19 Impact on Reproduction · Medicine · Immunology · Internal Medicine · Virology

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