Evaluation of cardiac hypertrophy in the setting of sudden cardiac death

Bibliographic Data

ID16964799
AuthorsKristopher S Cunningham (University of Toronto, corresponding author), Danna A Spears (0000-0002-2513-1627, University Health Network), Melanie Care (0000-0001-7651-5244, Mount Sinai Hospital)
Year2019
Volume4
Issue3
Pages223-240
Publication date2019-07-03
Open AccessYes
TypeARTICLE
VenueForensic Sciences Research (JOURNAL)
Journal identifiersISSN: 2471-1411 • E-ISSN: 2096-1790
PublisherShanghai Institute of Optics and Fine Mechanics (PUBLISHER • CN)
DOI10.1080/20961790.2019.1633761
PMID31489388
OpenAlexW2969378084
LanguageEN
References cited100

Ventricular hypertrophy is a common pathological finding at autopsy that can act as a substrate for arrhythmogenesis. Pathologists grapple with the significance of ventricular hypertrophy when assessing the sudden and unexpected deaths of young people and what it could mean for surviving family members. The pathological spectrum of left ventricular hypertrophy (LVH) is reviewed herein. This article is oriented to the practicing autopsy pathologist to help make sense of various patterns of increased heart muscle, particularly those that are not clearly cardiomyopathic, yet present in the setting of sudden cardiac death. The article also reviews factors influencing arrhythmogenesis as well as genetic mutations most commonly associated with ventricular hypertrophy, especially those associated with hypertrophic cardiomyopathy (HCM)

Autopsy · Blood pressure · Cardiac hypertrophy · Cardiology · Cardiomyopathy · Heart failure · Hypertrophic cardiomyopathy · Left ventricular hypertrophy · Muscle hypertrophy · Pathological · Sudden cardiac death · Sudden death · Ventricular hypertrophy · Cardiomyopathy and Myosin Studies · Cardiovascular Effects of Exercise · Medicine · Viral Infections and Immunology Research · Internal Medicine

Tools

Open DOISci-HubOpen Access