Mechanistic insights into xanthomicrol as the active anti-HCC ingredient of Phytolacca acinosa Roxb

A network pharmacology analysis and transcriptomics integrated experimental verification

Bibliographic Data

ID17637742
AuthorsJiayao Liu (0009-0004-8006-0421, Guangdong Provincial People's Hospital), Yang Zhou (0000-0002-4537-9857, South China University of Technology), Pincheng Zhou (Guangdong Academy of Medical Sciences), Ting He (0000-0001-7805-2482, Guangdong Academy of Medical Sciences), Pengcheng Liu (0000-0002-0874-1538, Southern Medical University), Jie Wang (0000-0003-3564-6808, Guangdong Academy of Medical Sciences), Peixu Lin (Guangdong Provincial People's Hospital), Jialing Hou (Guangdong Provincial People's Hospital), Sun Huan-huan (Southern Medical University, corresponding author), Huanhuan Sun, Haiqing Ma (0000-0001-8716-0928, South China University of Technology, corresponding author)
Year2024
Volume333
Pages118467-118467
Publication date2024-06-21
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2024.118467
PMID38909826
OpenAlexW4399898804
LanguageEN
References cited12

Xanthomicrol, a principal active component of PAR, has been identified to impede the growth of HCC by targeting the PI3K/Akt/MMP9 pathway. This insight could enhance therapeutic approaches for HCC

Active ingredient · Biological activity · Biology · In vitro · Pharmacognosy · Traditional medicine · Medicine · Metabolomics and Mass Spectrometry Studies · Natural product bioactivities and synthesis · Pharmacological Effects of Natural Compounds · Biochemistry · Pharmacology

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