Racial and Sex Differences between Urinary Phthalates and Metabolic Syndrome among U.S. Adults
Nhanes 2005–2014
Bibliographic Data
| ID | 17801143 |
|---|---|
| Authors | Rajrupa Ghosh (0009-0008-5330-870X, University of Maryland, College Park), Mefruz Salwa Haque (University of Maryland, College Park), Paul C Turner (0000-0001-7744-891X, University of Maryland, College Park), Raul Cruz-Cano (0000-0001-7715-1198, University of Maryland, College Park), Cher M Dallal (0000-0002-7946-3969, University of Maryland, College Park, corresponding author) |
| Year | 2021 |
| Volume | 18 |
| Issue | 13 |
| Pages | 6870-6870 |
| Publication date | 2021-06-26 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph18136870 |
| PMID | 34206929 |
| OpenAlex | W3174957799 |
| Language | EN |
| Citations received | 2 |
| References cited | 4 |
Phthalates, plasticizers ubiquitous in household and personal care products, have been associated with metabolic disturbances. Despite the noted racial differences in phthalate exposure and the prevalence of metabolic syndrome (MetS), it remains unclear whether associations between phthalate metabolites and MetS vary by race and sex. A cross-sectional analysis was conducted among 10,017 adults from the National Health and Nutritional Examination Survey (2005-2014). Prevalence odds ratios (POR) and 95% confidence intervals (CIs) were estimated for the association between 11 urinary phthalate metabolites and MetS using weighted sex and race stratified multivariable logistic regression. Higher MCOP levels were significantly associated with increased odds of MetS among women but not men, and only remained significant among White women (POR Q4 vs. Q1 = 1.68, 95% CI: 1.24, 2.29; p -trend = 0.001). Similarly, the inverse association observed with MEHP among women, persisted among White women only (POR Q4 vs. Q1 = 0.53, 95% CI: 0.35, 0.80; p -trend = 0.003). However, ΣDEHP metabolites were associated with increased odds of MetS only among men, and this finding was limited to White men (POR Q4 vs. Q1 = 1.54, 95% CI: 1.01, 2.35; p -trend = 0.06). Among Black men, an inverse association was observed with higher MEP levels (POR Q4 vs. Q1 = 0.43, 95% CI: 0.24, 0.77; p -trend = 0.01). The findings suggest differential associations between phthalate metabolites and MetS by sex and race/ethnicity
Confidence interval · Environmental health · Logistic regression · Metabolic syndrome · National Health and Nutrition Examination Survey · Obesity · Odds ratio · Phthalate · Population · Chemistry · Demography · Effects and risks of endocrine disrupting chemicals · Medicine · Internal Medicine
| Citations per year | 0.5 |
|---|---|
| Citation span | 2022 - 2025 (4) |
| Highly cited | No |