Non-linear association between Mediterranean diet and depressive symptom in U.S. adults

A cross-sectional study

Bibliographic Data

ID17801295
AuthorsYaohua Fan (0000-0002-1287-3760, Guangzhou University of Chinese Medicine), Lijun Zhao (0000-0002-2305-1914), Lijun Liz Zhao (0000-0002-8935-001X, Guangzhou University of Chinese Medicine), Zhiyuan Deng (0009-0004-8190-9597, Gaozhou People's Hospital), Mengzhu Li (0000-0003-1814-3176, Guangzhou University of Chinese Medicine), Zifeng Huang (0000-0002-1199-291X, Guangzhou University of Chinese Medicine), Meiling Zhu (0000-0003-3798-5547, Guangzhou University of Chinese Medicine, corresponding author), Wenhua Xu (0000-0001-5552-0183, Guangzhou University of Chinese Medicine, corresponding author)
Year2022
Volume13
Pages936283-936283
Publication date2022-07-15
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2022.936283
PMID35911213
OpenAlexW4285591399
LanguageEN
Citations received1
References cited46

The Mediterranean diet (MED), a dietary pattern rich in fruits and vegetables, whole grains, legumes, nuts, fish, and olive oil, has anti-oxidative and anti-inflammatory effects. Although some data suggest that MED adherence is associated with decreased manifestation of depressive symptoms, it remains necessary to further analyze this apparent non-linear association as well as the influence of different factors on the relationship between MED and depression. Here, we investigated associations between the alternate MED (aMED) score and depressive symptom via multivariate logistic regression, weighted generalized additive (GAM) and two-step linear regression models, analyzing data from the 2005-2018 National Health and Nutrition Examination Survey (NHANES). The most important factor relevant to aMED score that contributed to the prevalence of depressive symptom was assessed using random forest. Furthermore, we examined whether the relationship between aMED score and depressive symptom differs by age, race, sex, socioeconomic variables, lifestyle- and health-related variables, and chronic medical conditions, via subgroup analyses. A total of 19,477 participants (20-80 years of age) were included in this cross-sectional study. In crude and adjusted (1-5) multivariate logistic regression models, increased aMED score was noted to associate with non-depressive status, as defined using the Patient Health Questionnaire-9 ( P via GAM and two-piecewise linear regression revealed a non-linear association between aMED and depressive symptom, which had an inflection point of 3. Random forest results revealed that vegetable score contributes greatest to the relationship between aMED and depressive symptom. Subgroup analyses revealed that aMED score is significantly negatively related with depressive symptom in most different populations ( P P > 0.05). In conclusion, we observed a non-linear association between aMED score and depressive symptom. Further studies are needed to validate our results

Cognition · Cross-sectional study · Depressive symptoms · Mediterranean diet · Pathology · Psychiatry · Clinical Psychology · Demography · Diet and metabolism studies · Diet, Metabolism, and Disease · Medicine · Nutritional Studies and Diet · Psychology · Gerontology · Internal Medicine

Tools

Open DOIOpen Access