Evolutionary medicine approaches to chronic disease
The case of irritable bowel syndrome
Bibliographic Data
| ID | 18942909 |
|---|---|
| Authors | Makenna B Lenover Moyer (0000-0003-1147-2225, Department of Anthropology The Pennsylvania State University State College Pennsylvania USA, corresponding author), M K Shenk (0000-0003-2002-1469, Department of Anthropology The Pennsylvania State University State College Pennsylvania USA) |
| Year | 2024 |
| Volume | 33 |
| Issue | 1 |
| Pages | e22010-e22010 |
| Publication date | 2024-02-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Evolutionary Anthropology Issues News and Reviews (JOURNAL) |
| Journal identifiers | ISSN: 1060-1538 • E-ISSN: 1520-6505 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/evan.22010 |
| PMID | 37909359 |
| OpenAlex | W4388125969 |
| Language | EN |
| Citations received | 1 |
| References cited | 82 |
Irritable bowel syndrome (IBS), a gastrointestinal disease, is a global phenomenon correlated with industrialization. We propose that an evolutionary medicine approach is useful to understand this disease from an ultimate perspective and conducted a scoping literature review to synthesize the IBS literature within this framework. Our review suggests five potential evolutionary hypotheses for the cause of IBS, including (a) a dietary mismatch accompanying a nutritional transition, (b) an early hygienic life environment leading to the immune system and microbiotic changes, (c) an outcome of decreased physical activity, (d) a response to changes in environmental light–dark cycles, and (e) an artifact of an evolved fight or flight response. We find key limitations in the available data needed to understand early life, nutritional, and socioeconomic experiences that would allow us to understand evolutionarily relevant risk factors and identify a need for further empirical research to distinguish potential causes and test evolutionary hypotheses
Disease · Evolutionary medicine · Intensive care medicine · Irritable bowel syndrome · Pathology · Psychiatry · Computer Science · Diet and metabolism studies · Dietary Effects on Health · Gastrointestinal motility and disorders · Medicine · Psychology
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| Citations per year | 1 |
|---|---|
| Citation span | 2025 - 2025 (1) |
| Highly cited | No |