Relationship between bone density of paranasal sinuses and adrenal steroids pattern in women during menopausal transition

Bibliographic Data

ID18975311
AuthorsVitaliy Gargin (0000-0001-8194-4019, Kharkiv National Medical University, corresponding author), Iryna Muryzina, Muryzina Iryna (Kharkiv National Medical University), Nikolay Shcherbina (0000-0001-9934-5639, Kharkiv National Medical University), Alina Nechyporenko (0000-0003-2494-1465, Kharkiv National University of Radio Electronics), Victoria Baryshevska, Baryshevska Victoria (Kharkiv Medical Academy of Postgraduate Education), Olga Vorobyova (0000-0001-9039-9737, State Enterprise "L.I. Medved's Research Center of Preventive Toxicology, Food and Chemical Safety" of the Ministry of Health of Ukraine), Victoriia Alekseeva, Alekseeva Victoriia (Kharkiv National Medical University)
Year2020
Volume83
Issue4
Pages407-418
Publication date2020-12-30
Open AccessYes
TypeARTICLE
VenueAnthropological Review (JOURNAL)
Journal identifiersISSN: 1898-6773 • E-ISSN: 2083-4594
PublisherUniwersytet Lodzki (University of Lodz) (PUBLISHER)
DOI10.2478/anre-2020-0031
OpenAlexW3112956296
LanguageEN
References cited23

The course of menopause transition (MT) is associated with peculiarities of alterations occurring in a woman’s body, in particular, in the structure of bone tissue. Considering that bones of the paranasal sinuses (BPNSs) play a natural defense role against the spread of dental infection, their structure is important in dentistry. However, no information was found pertaining to changes of BPNSs during MT – a time when dental maladies increase in many women. The aim of our study was to collate density of BPNSs with status of adrenal steroids in women during MT, since the pattern of their changes determines the course of MT. Cross-sectional associations were examined between bone density of PNSs assessed by Spiral Computed Tomography and Serum content of testosterone (T), sex hormone binding globulin (SHBG), free androgen index (FAI), insulin, dehydroepiandrosterone sulfate (DHEAS), Adione, and Adiol in 113 women of per­imenopausal age (age range from 45 to 55 years) who had already experienced premenopausal menstrual decline (amenorrhea less than 2 years). Strong positive (r = 0.73) correlation between minimal bone density of maxillary sinus in women with level of DHEAS was detected. It is important to note, that the correlation between minimal density of the lower wall of frontal sinus is a weak positive (0.3). Therefore , it can be suggested that bone tissue of the maxillary sinus is more sensitive to changes in DHEAS. The study showed that the level of male steroids, in particular DHEAS, affected the state of bone tissue in participants older than 50 years of age

Amenorrhea · Androgen · Biology · Bone density · Dehydroepiandrosterone sulfate · Free androgen index · Hormone · Menopause · Osteoporosis · Paranasal sinuses · Pregnancy · Sex hormone-binding globulin · Healthcare Systems and Public Health · Medical and Biological Sciences · Medicine · Endocrinology · Internal Medicine · Surgery

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