Hepatic toxicity induced by dietary treatment of rats with hexaconazole
Insights from a cytotoxic and genotoxic study
Bibliographic Data
| ID | 19268428 |
|---|---|
| Authors | Mariam Jalal (0000-0002-8128-0379, Faculty of Science, Laboratory of Cell Biology and Molecular Genetics, University Ibn Zohr, Agadir, Morocco, corresponding author), Latifa Ez-Zaher (0009-0000-0438-1208, Faculty of Science, Laboratory of Cell Biology and Molecular Genetics, University Ibn Zohr, Agadir, Morocco), Saïd Chouham (0000-0002-2666-2913, Faculty of Science, Laboratory of Cell Biology and Molecular Genetics, University Ibn Zohr, Agadir, Morocco) |
| Year | 2024 |
| Volume | 81 |
| Issue | 5 |
| Pages | 2168-2182 |
| Publication date | 2024-09-02 |
| Open Access | No |
| Type | ARTICLE |
| Venue | International Journal of Environmental Studies (JOURNAL) |
| Journal identifiers | ISSN: 0020-7233 • E-ISSN: 1026-7476 |
| Publisher | Informa UK Limited (PUBLISHER • GB) |
| DOI | 10.1080/00207233.2024.2350849 |
| OpenAlex | W4396733377 |
| Language | EN |
| References cited | 44 |
Hexaconazole (HEX), a widely used triazole fungicide in agriculture, was investigated for its hepatotoxic effects on albino Wistar rats. Compared to the control rats, the treated rats showed a significant increase in absolute and relative liver weight over both 3 months (p < 0.05) and 6 months (p < 0.001). Oxidative biomarkers indicated a notable rise in malondialdehyde (MDA) by 137% (p < 0.001), increased reduced glutathione (GSH) by 32% (p < 0.01), and significant reductions in antioxidant enzymes, including a 63% decrease in catalase (CAT, p < 0.001) and a 15% decrease in superoxide dismutase (SOD, p < 0.01). Glutathione-S-transferase (GST) levels also decreased significantly after 3 and 6 months (p < 0.05). The micronucleus test in liver cells indicated an elevation in the appearance of micronuclei in rats treated with HEX for 6 months (p < 0.01). This study demonstrates, for the first time, that HEX can induce genotoxicity in the liver
Biology · Botany · Cytotoxic T cell · Fungicide · Genotoxicity · Hexaconazole · In vitro · Toxicity · Biochemistry · Carcinogens and Genotoxicity Assessment · Chemistry · Drug-Induced Hepatotoxicity and Protection · Internal Medicine · Medicine · Pharmacogenetics and Drug Metabolism · Pharmacology
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| Highly cited | No |
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