Very long-term outcome of psychotic disorders

Bibliographic Data

ID19271972
AuthorsVaios Peritogiannis (0000-0002-9825-154X, Mobile Mental Health Unit of the Prefectures of Ioannina and Thesprotia, Society for the Promotion of Mental Health in Epirus, Ioannina, Greece, corresponding author), Afroditi Gogou (Mobile Mental Health Unit of the Prefectures of Ioannina and Thesprotia, Society for the Promotion of Mental Health in Epirus, Ioannina, Greece), Maria Samakouri (0000-0002-3173-0474, Department of Psychiatry, Medical School, Democritus University of Thrace, Thrace, Greece)
Year2020
Volume66
Issue7
Pages633-641
Publication date2020-11-01
Open AccessYes
TypeARTICLE
VenueInternational Journal of Social Psychiatry (JOURNAL)
Journal identifiersISSN: 0020-7640 • E-ISSN: 1741-2854
PublisherSAGE Publications (PUBLISHER • US)
DOI10.1177/0020764020922276
PMID32507065
OpenAlexW3033768088
LanguageEN
Citations received2
References cited47

BACKGROUND: The outcome of schizophrenia and related psychoses is generally modest, and patients display high rates of disability. AIMS: The aim of the review is to present an up-to-date account of the research on the very long-term outcome of psychotic disorders. METHOD: We conducted a search in the PubMed and Scopus databases for articles published since the publication of the very long-term data of the World Health Organization's International Study of Schizophrenia (the ISoS study), over the last 18 years (from 2002 to 2019). Studies were included if they reported on at least 15-year outcome and if they had used valid and reliable tools for the estimation of the patients' outcome in terms of symptomatology and functioning. RESULTS: A total of 16 studies were included in this review, involving 1,391 patients with schizophrenia and related psychoses. Most were single-center studies, with moderate size samples of patients, and 11 were prospective studies. Very long-term outcome of psychotic disorders varies considerably among studies. Good outcome ranges from 8% to 73.8%, and it appears to be better in developing countries, whereas differences are less apparent among Western countries (8%-40.3%). Studies in different settings have used different methods involving a variety of samples of patients to estimate their outcome, whereas definitions of good and poor outcome also varied among studies. Longer duration of untreated psychosis was associated with worse outcome in some studies. Schizophrenia was found to have poorer long-term prognosis compared to other schizophrenia spectrum disorders. A large proportion of patients, ranging from 19% to 48.2%, were not on medication. CONCLUSION: Recent evidence on the very long-term outcome of psychotic disorders is in line with previous reports and suggests that prognosis remains rather modest. There are several limitations of current research regarding outcome definitions and study design that should be addressed by future research

Outcome (game theory) · Psychiatry · Psychosis · Schizophrenia (object-oriented programming) · Healthcare Decision-Making and Restraints · Medicine · Mental Health and Psychiatry · Psychology · Schizophrenia research and treatment

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