Abuse History, Depression, and Somatization Are Associated With Gastric Sensitivity and Gastric Emptying in Functional Dyspepsia

Bibliographic Data

ID19301182
AuthorsLukas Van Oudenhove (0000-0002-6540-3113, KU Leuven, corresponding author), Joris Vandenberghe (0000-0002-3744-0304), Rita De Vos, Rita Vos, Benjamin Fischler, Koen Demyttenaere (0000-0001-5331-487X), Jan Tack (0000-0002-3206-6704)
Year2011
Volume73
Issue8
Pages648-655
Publication date2011-10-01
Open AccessNo
TypeARTICLE
VenuePsychosomatic Medicine (JOURNAL)
Journal identifiersISSN: 0033-3174 • E-ISSN: 1534-7796
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/psy.0b013e31822f32bf
PMID21949416
OpenAlexW1975880603
LanguageEN
Citations received1
References cited53

In Brief Objective: Gastric sensitivity testing relies on subjective reporting and may therefore be influenced by psychosocial factors and somatization. Furthermore, psychological processes may affect gastric motor function (accommodation to a meal emptying) through efferent brain-gut pathways. This study sought to determine the association of abuse history, psychiatric comorbidity, and somatization with gastric sensorimotor function. Methods: In 201 patients with functional dyspepsia, gastric sensitivity and accommodation were studied with a barostat. Gastric emptying of solids was studied using a breath test. Sexual and physical abuse history, psychiatric comorbidity (depression and panic disorder), and somatization were assessed using validated questionnaires. Multiple linear regression models were used to identify patient characteristics independently associated with gastric sensitivity and emptying. Results: Age (p = .02), sexual abuse history (p < .001), physical abuse history (p = .004), and somatization (p < .001) were independently associated with gastric discomfort threshold (R2 = 0.30); a significant depression-by-sexual abuse interaction effect was also found (p = .003). None of the factors studied were associated with gastric accommodation to a meal. Physical abuse history (p = .003) and somatization (p = .048) were independently associated with gastric emptying (R2 = 0.19). Conclusions: These results demonstrate the complex relationship among abuse history, psychiatric comorbidity, somatization, and gastric sensorimotor (dys)function. Although the psychobiological mechanisms underlying these relationships remain to be determined, the autonomic nervous, stress hormone, and immune systems may be involved. FD = functional dyspepsia; FGID = functional gastrointestinal disorder; t1/2 = gastric half-emptying time; PHQ = Patient Health Questionnaire; GI = gastrointestinal; GLM = general linear model; IBS = irritable bowel syndrome; ANS = autonomic nervous system; CRF = corticotropin-releasing factor Supplemental digital content is available in the article

Anxiety · Comorbidity · Gastric emptying · Injury prevention · Poison control · Psychiatry · Psychosocial · Sexual abuse · Somatization · Stomach · Clinical Psychology · Gastroesophageal reflux and treatments · Gastrointestinal motility and disorders · Internal Medicine · Medicine · Music Therapy and Health · Psychology

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