Anxiety Increases Acid-Induced Esophageal Hyperalgesia
Bibliographic Data
| ID | 19301403 |
|---|---|
| Authors | Abhishek Sharma (0000-0002-4961-6258, Salford Royal NHS Foundation Trust), Lukas Van Oudenhove (0000-0002-6540-3113), Peter Paine (0000-0003-4131-9651), Lloyd Gregory, Lloyd J Gregory, Qasim Aziz (0000-0002-2718-2065, corresponding author) |
| Year | 2010 |
| Volume | 72 |
| Issue | 8 |
| Pages | 802-809 |
| Publication date | 2010-10-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Psychosomatic Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0033-3174 • E-ISSN: 1534-7796 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/psy.0b013e3181f5c021 |
| PMID | 20841561 |
| OpenAlex | W1965302259 |
| Language | EN |
| Citations received | 1 |
| References cited | 36 |
OBJECTIVE: Anxiety at the time of gastrointestinal injury or inflammation increases the risk of developing visceral hyperalgesia. Distal esophageal acidification induces hyperalgesia in the non-acid exposed proximal esophagus, due to the sensitization of spinal dorsal horn neurones. The objective was to determine whether anxiety influences acid-induced hyperalgesia. METHODS: A total of 19 healthy volunteers (n = 12 females; age, 22-57 years; mean, 35.7 years) completed a 10-minute mood induction paradigm (anxiety or neutral) with autonomic monitoring (visit 1). On visits 2 and 3, pain thresholds to electrical stimulation, in milliamperes (mA), were determined in the proximal esophagus and foot (control) before and after a 30-minute infusion of 0.15 M of hydrochloric acid. During esophageal acid infusion, the subjects randomly received anxiety or neutral mood induction with autonomic monitoring, in a crossover design. Anxiety and pain ratings were recorded pre and post infusion. RESULTS: Visit 1: Anxiety induction increased anxiety scores (p < .001), mean arterial pressure (p < .001), and cardiac sympathetic index (p = .007), and reduced parasympathetic measures (cardiac vagal tone [p = .05] and cardiac sensitivity to baroreflex [p = .006)]). Visit 2: Anxiety induction conferred greater acid-induced hyperalgesia compared with neutral (-4.9 mA versus 2.7 mA, p = .009, analysis of covariance). No differences in autonomic measures were found during acid infusion with anxiety or neutral mood induction. CONCLUSIONS: Anxiety induction increases acid-induced esophageal hyperalgesia; anxiety, thus, facilitates central sensitization in the esophagus. Our studies provide a new model for studying the effects of anxiety on esophageal hyperalgesia and may allow testing of therapeutic strategies to reduce this effect
Anesthesia · Anxiety · Hyperalgesia · Nociception · Psychiatry · Clinical Psychology · Gastroesophageal reflux and treatments · Gastrointestinal motility and disorders · Internal Medicine · Medicine · Pathogenesis and Treatment of Hiccups · Psychology
| Citations per year | 0.1 |
|---|---|
| Citation span | 2016 - 2016 (1) |
| Highly cited | No |