Stress-Induced Alterations in Coagulation
Assessment of a New Hemoconcentration Correction Technique
Bibliographic Data
| ID | 19301786 |
|---|---|
| Authors | Anthony W Austin (0000-0002-3275-5948, Bridge University, corresponding author), Petra H Wirtz (0000-0002-4897-1645, Bridge University), Stephen Patterson (0000-0002-6312-7194, Bridge University), Stephen M Patterson, Monika Stutz (Bridge University), Roland Von Känel (0000-0002-8929-5129, Bridge University) |
| Year | 2012 |
| Volume | 74 |
| Issue | 3 |
| Pages | 288-295 |
| Publication date | 2012-04-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Psychosomatic Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0033-3174 • E-ISSN: 1534-7796 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/psy.0b013e318245d950 |
| PMID | 22366587 |
| OpenAlex | W2079785181 |
| Language | EN |
| Citations received | 4 |
| References cited | 22 |
OBJECTIVE: For the examination of psychological stress effects on coagulation, the Dill and Costill correction (DCC) for hemoconcentration effects has been used to adjust for stress-induced plasma volume changes. Although the correction is appropriate for adjusting concentrations of various large blood constituents, it may be inappropriate for time-dependent or functional coagulation assays. Two new plasma reconstitution techniques for correcting hemoconcentration effects on stress-induced changes in coagulation were compared with the DCC. METHODS: Blood was collected from 31 men during baseline, the Trier Social Stress Test (TSST), and after 20-minute recovery. For the reconstitution techniques, TSST plasma samples were reconstituted with either baseline plasma or physiological saline equal to the amount of plasma lost during stress. RESULTS: Uncorrected activated partial thromboplastin time (APTT) decreased, whereas fibrinogen, factor VIII clotting activity (FVIII:C), D-dimer and prothrombin time (PT%) increased significantly during the TSST. The DCC produced a significantly greater decrease in APTT during stress compared to uncorrected APTT, a significant decrease in PT% compared to uncorrected PT%, and stress D-dimer and fibrinogen and FVIII:C being no different than baseline. APTT, fibrinogen, D-dimer and PT% after saline reconstitution were not different from baseline, whereas FVIII:C after saline reconstitution remained elevated. APTT, PT%, fibrinogen and D-dimer after plasma reconstitution were no different from uncorrected values, whereas FVIII:C remained significantly elevated. CONCLUSIONS: The observed changes in coagulation are likely in part a consequence of stress and hemoconcentration, but the DCC seems to be an inappropriate hemoconcentration correction technique of time-dependent assays. The saline reconstitution technique may be more biologically relevant when examining stress-hemoconcentration effects on coagulation
Clotting time · Coagulation · Fibrinogen · Hematocrit · Hemoconcentration · Partial thromboplastin time · Prothrombin time · Saline · Blood properties and coagulation · Chemistry · Endocrinology · Internal Medicine · Medicine · Sepsis Diagnosis and Treatment · Trauma, Hemostasis, Coagulopathy, Resuscitation
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Challenges in Controlling for the Effects of Hematoconcentration
The Role of Norepinephrine and α-Adrenergic Receptors in Acute Stress-Induced Changes in Granulocytes and Monocytes
Reply to Letters From Fall and Bailey, and Muldoon
The epidemiology, pathophysiology, and management of psychosocial risk factors in cardiac practice
Impact of Psychological Factors on the Pathogenesis of Cardiovascular Disease and Implications for Therapy
The ‘Trier Social Stress Test’ – A Tool for Investigating Psychobiological Stress Responses in a Laboratory Setting
Behavioral and Emotional Triggers of Acute Coronary Syndromes
Influence of Socioeconomic Status and Job Control on Plasma Fibrinogen Responses to Acute Mental Stress
Anticipatory Cognitive Stress Appraisal and the Acute Procoagulant Stress Response in Men
| Citations per year | 0.31 |
|---|---|
| Citation span | 2013 - 2018 (6) |
| Highly cited | No |